INT222080

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.22
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90b1) protein folding (Hsp90b1) cytosol (Hsp90b1)
endoplasmic reticulum (Hsp90b1) RNA binding (Hsp90b1) response to stress (Hsp90b1)
Anatomy Link Frequency
muscle fibers 4
neurons 2
skeletal muscle 2
Hsp90b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 105 99.74 Very High Very High Very High
Calcium channel 7 72.24 Quite High
Inflammatory stimuli 9 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
gABA 4 5.00 Very Low Very Low Very Low
TRP channel 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myositis 126 99.96 Very High Very High Very High
Stress 106 98.28 Very High Very High Very High
INFLAMMATION 87 97.08 Very High Very High Very High
Lysosomal Storage Diseases 24 50.64 Quite High
Death 9 47.16 Quite Low
Disease 27 24.56 Low Low
Lysosome Storage Disease 6 21.04 Low Low
Disorders Of Creatine Metabolism 9 8.72 Low Low
Manic Depressive Disorder 19 5.00 Very Low Very Low Very Low
Muscle Weakness 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that valproate and lithium can modulate GRP94 expression in neurons [23], raising the possibility that this interaction can also be modulated with valproate and lithium.
Regulation (modulate) of Gene_expression (expression) of GRP94 in neurons
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0 Pain Relevance 0
The aim of the present study was therefore to investigate the stress-response ongoing in muscle fibers of patients affected with inflammatory myopathies, focusing on Grp94, calreticulin and Grp75 expression and distribution.
Regulation (focusing) of Gene_expression (expression) of Grp94 in muscle fibers associated with stress and inflammation
2) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.61 Pain Relevance 0.12
We then looked for an experimental condition that would be stressful for skeletal muscle without affecting Grp94 expression in myofibers.
Neg (without) Regulation (affecting) of Gene_expression (expression) of Grp94 in skeletal muscle
3) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.28 Pain Relevance 0.09
Nonregenerating muscle fibers from myositis patients apparently did not vary their Grp94 expression.
Neg (not) Regulation (vary) of Gene_expression (expression) of Grp94 in muscle fibers associated with myositis
4) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.28 Pain Relevance 0.09
That the expression levels of GRP94, Hsp70, calnexin, and calreticulin were not changed significantly was also confirmed at the protein level.
Neg (not) Regulation (changed) of Gene_expression (expression) of GRP94
5) Confidence 0.14 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0.05 Pain Relevance 0.04

General Comments

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