INT222087

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 5
Speculated 2
Reported most in Body
Documents 3
Total Number 13
Disease Relevance 0.56
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Calr) Golgi apparatus (Calr) endoplasmic reticulum (Calr)
cytoplasm (Calr) cytosol (Calr) protein folding (Calr)
Anatomy Link Frequency
CPA 2
Calr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 35 95.86 Very High Very High Very High
Calcium channel 34 77.12 Quite High
ketamine 10 47.68 Quite Low
anesthesia 12 45.92 Quite Low
Central nervous system 14 5.00 Very Low Very Low Very Low
Glutamate 10 5.00 Very Low Very Low Very Low
TRP channel 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 29 95.86 Very High Very High Very High
Coronary Heart Disease 10 84.88 Quite High
Myositis 42 81.92 Quite High
American Trypanosomiasis 40 52.72 Quite High
Lysosomal Storage Diseases 48 50.64 Quite High
Stress 40 50.00 Quite Low
Sprains And Strains 4 27.44 Quite Low
Lysosome Storage Disease 12 21.04 Low Low
Disease 24 7.64 Low Low
Gauchers Disease 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under this condition the amount of cytosolic TcCRT was no altered compared with that of untreated parasites (Figure 1C and D).
Neg (no) Regulation (altered) of TcCRT
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
Under this condition cytosolic TcCRT increased after the addition of CPA and its level remained steadily high (Figure 2C and D), suggesting that TcCRT concentration in the cytosol might be regulated by proteasomal degradation.


Spec (might) Regulation (regulated) of TcCRT in CPA
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
It has been recently suggested that nuclear export of androgen receptor is independent of CRT [60].
Neg (independent) Regulation (independent) of CRT
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
More important, the amount of biotinylated TcCRT was not affected by CPA addition (Figure 7).
Neg (not) Regulation (affected) of TcCRT in CPA
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
Finally, evidence presented here and previous results by others suggest that the regulation of CRT retrotranslocation by calcium could be a crossroad between diverse signaling pathways.
Regulation (regulation) of CRT
5) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
However, at variance with ERAD substrates and bacterial toxins, we propose that CRT retrotranslocation is modulated by structural modifications triggered by variations of ER calcium levels.
Regulation (modulated) of CRT
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0.03
We recently found that the conformation of CRT-C is affected by calcium in a concentration range similar to that spanned by the cation in the ER under physiological fluctuations [37].
Regulation (affected) of CRT
7) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0.14 Pain Relevance 0
According to this model, ER calcium depletion would trigger a conformational change on CRT-C toward a more disordered structure.
Regulation (change) of CRT
8) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0.06 Pain Relevance 0
Given the myriad of cellular responses mediated by calcium, many of the biological effects observed upon changes in CRT levels might originate from an imbalance of calcium homeostasis.
Regulation (changes) of CRT
9) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
These results show that ER calcium level regulates the C-terminal-dependent retrotranslocation of TcCRT.
Regulation (regulates) of TcCRT
10) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0.04
We previously reported that systemic inflammation induced by a single LPS injection did not change Grp94 expression in rabbit adult skeletal myofibers [24] - we therefore applied the same experimental protocol to the mouse to investigate whether Grp75 and calreticulin levels were affected.
Spec (whether) Regulation (affected) of calreticulin associated with inflammation
11) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.31 Pain Relevance 0.12
That the expression levels of GRP94, Hsp70, calnexin, and calreticulin were not changed significantly was also confirmed at the protein level.
Neg (not) Regulation (changed) of calreticulin
12) Confidence 0.09 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0.05 Pain Relevance 0.04
The mRNA expression levels of BiP, Hsp40, and Hsp90 were increased up to 1.8-fold, 1.8-fold, and 1.9-fold, respectively, after a 7-d treatment with diltiazem, whereas the mRNA expression levels of Hsp70, GRP94, calnexin, and calreticulin were not changed significantly.
Neg (not) Regulation (changed) of calreticulin
13) Confidence 0.05 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0

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