INT222088

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.37
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Dnajb1) protein folding (Dnajb1) nucleus (Dnajb1)
response to stress (Dnajb1) cytoplasm (Dnajb1)
Anatomy Link Frequency
brain structures 1
fibroblasts 1
Dnajb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 516 99.92 Very High Very High Very High
Calcium channel 43 92.24 High High
medulla 5 86.48 High High
Neurotransmitter 1 68.68 Quite High
fibrosis 13 62.96 Quite High
Opioid 84 53.36 Quite High
depression 4 49.76 Quite Low
Hippocampus 13 43.20 Quite Low
opiate 12 32.16 Quite Low
cocaine 3 28.88 Quite Low
Disease Link Frequency Relevance Heat
Shock 44 100.00 Very High Very High Very High
Stress 24 100.00 Very High Very High Very High
Sprains And Strains 246 99.28 Very High Very High Very High
Paralysis 2 79.48 Quite High
Hypothermia 6 68.88 Quite High
Apoptosis 26 66.80 Quite High
Cystic Fibrosis 13 63.52 Quite High
Lysosomal Storage Diseases 144 62.88 Quite High
Targeted Disruption 7 56.88 Quite High
Hypoxia 3 52.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Hspa1b was highly correlated with mRNA levels of other heat shock proteins, namely heat shock protein 72 (Hspa1a) and heat shock protein 40 (Dnajb1).
Gene_expression (Expression) of heat shock protein 40 associated with shock
1) Confidence 0.65 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.85 Pain Relevance 0.45
Co-expression of three genes that are typically associated with cellular stress and temperature stimulus (Hspa1a, Haspa1b, and Dnajb1) was detected after morphine treatment.
Gene_expression (expression) of Dnajb1 associated with stress and morphine
2) Confidence 0.58 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.97 Pain Relevance 1.06
Expression of Hspa1b was highly correlated with mRNA levels of other heat shock proteins, namely heat shock protein 72 (Hspa1a) and heat shock protein 40 (Dnajb1).
Gene_expression (Expression) of Dnajb1 associated with shock
3) Confidence 0.58 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.85 Pain Relevance 0.45
In contrast to predictions based on the ABA database, protein levels of DnaJb1 were not variable across brain structures (Figure 12B).
Gene_expression (levels) of DnaJb1 in brain structures
4) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0 Pain Relevance 0.04
The mRNA expression levels of BiP, Hsp40, and Hsp90 were increased up to 1.8-fold, 1.8-fold, and 1.9-fold, respectively, after a 7-d treatment with diltiazem, whereas the mRNA expression levels of Hsp70, GRP94, calnexin, and calreticulin were not changed significantly.
Gene_expression (expression) of Hsp40
5) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0
The increased protein expression levels of BiP, Hsp40, and Hsp90 were confirmed after a 7-d treatment with diltiazem.
Gene_expression (expression) of Hsp40
6) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0.03
These increases in molecular chaperone expression levels, especially the cytoplasmic Hsp40 levels, seem to account for the increased GC folding capacity of the ER, and the requirement for new transcription may also contribute to the relatively slow increases in lysosomal enzyme levels upon calcium channel blocker treatment.
Gene_expression (levels) of Hsp40 associated with calcium channel
7) Confidence 0.10 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0.06 Pain Relevance 0.05
The mRNA expression levels of BiP, Hsp40, and Hsp90 were increased up to 1.8-fold, 1.8-fold, and 1.9-fold, respectively, after a 7-d treatment with diltiazem, whereas the mRNA expression levels of Hsp70, GRP94, calnexin, and calreticulin were not changed significantly.
Gene_expression (levels) of Hsp40
8) Confidence 0.09 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0
The relative mRNA expression levels of representative cytoplasmic and ER lumenal chaperones—including Hsp40, Hsp70, BiP, Hsp90, GRP94, calnexin, calreticulin, HIP, and HOP—were probed and normalized to the levels found in untreated cells (Figure 4A).
Gene_expression (expression) of Hsp40
9) Confidence 0.09 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0
A strictly analogous RT-PCR analysis of N370S/V394L GC fibroblasts reveals similarly increased mRNA expression levels of Hsp40, however BiP and Hsp90 exhibit less of an increase after 7 d of diltiazem treatment (Figure S5).
Gene_expression (expression) of Hsp40 in fibroblasts
10) Confidence 0.09 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0 Pain Relevance 0
Following activation of the heat shock response, another member of the J protein family, Hsp40 (heat shock protein of 40kDa) assembles with the CSP?
Gene_expression (assembles) of Hsp40 associated with shock
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883571 Disease Relevance 0.64 Pain Relevance 0.10

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