INT22213

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Context Info
Confidence 0.78
First Reported 1982
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 52
Total Number 53
Disease Relevance 34.05
Pain Relevance 12.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cytoplasm (Gpt)
Anatomy Link Frequency
liver 11
thyroid 4
hepatocytes 2
testis 2
nucleus 1
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 4 100.00 Very High Very High Very High
Paracetamol 157 99.82 Very High Very High Very High
carbamazepine 10 99.28 Very High Very High Very High
cytokine 35 98.76 Very High Very High Very High
halothane 60 98.38 Very High Very High Very High
Potency 49 97.32 Very High Very High Very High
Inflammation 67 97.04 Very High Very High Very High
Glutamate 15 96.64 Very High Very High Very High
nud 32 94.00 High High
fibrosis 51 91.20 High High
Disease Link Frequency Relevance Heat
Injury 117 100.00 Very High Very High Very High
Hepatotoxicity 87 100.00 Very High Very High Very High
Hepatitis C Virus Infection 47 99.84 Very High Very High Very High
Hepatitis B Virus Infection 306 99.82 Very High Very High Very High
Hepatocellular Cancer 181 99.72 Very High Very High Very High
Targeted Disruption 7 99.38 Very High Very High Very High
Chronic Hepatitis 144 99.00 Very High Very High Very High
Hepatitis 129 98.50 Very High Very High Very High
Cancer 28 98.40 Very High Very High Very High
Acute Liver Failure 35 98.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the PARP-activity remained essentially unchanged, the acetaminophen-induced release of both GOT and GPT from injured liver cells could be inhibited by 90-99%, when mice were injected additionally with the selective PARP-inhibitors nicotinic acid amide, benzamide, caffeine, theophyline, and thymidine, respectively.
Localization (release) of GPT in liver associated with paracetamol
1) Confidence 0.78 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8742516 Disease Relevance 0.24 Pain Relevance 0.54
The acetaminophen-induced release of both GOT and GPT from injured liver cells could be inhibited in a dose-dependent manner, when mice were injected additionally either with increasing amounts (from (25 mg/kg to 100 mg/kg i.p.) of the PARP-inhibitor nicotinamide, with increasing amounts (from 25 mg/kg to 100 mg/kg i.p.) of the antioxidant N-acetylcysteine, or with increasing amounts (from 50 mg/kg to 300 mg/kg i.p.) of the amino acid L-methionine. 4.
Localization (release) of GPT in liver associated with paracetamol
2) Confidence 0.78 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9013204 Disease Relevance 0.25 Pain Relevance 0.51
However, a significant inhibition (p<0.05) in the elevation of AST and ALT was observed in mice that received UBG and GIBG compared with APAP-treated mice.
Localization (elevation) of ALT associated with paracetamol
3) Confidence 0.72 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19109935 Disease Relevance 0.68 Pain Relevance 0.77
Poly I-C pretreatment produced a 5-fold increase in acetaminophen-induced ALT release (P less than 0.05), which correlated with histologic evidence of centrilobular necrosis.
Localization (release) of ALT in Poly associated with necrosis and paracetamol
4) Confidence 0.72 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2262910 Disease Relevance 0.57 Pain Relevance 0.85
A combination of both nicotinamide and N-acetylcysteine (at the low dose of 12.5 mg/kg i.p. each) results in a complete protection from acetaminophen-induced release of GOT and GPT from injured liver cells. 5.
Localization (release) of GPT in liver associated with paracetamol
5) Confidence 0.68 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9013204 Disease Relevance 0.20 Pain Relevance 0.54
A combination of both L-methionine and N-acetylcysteine or nicotinamide (at the low dose of 12.5 mg/kg IP each) resulted also in complete protection from acetaminophen-induced release of GOT and GPT.
Localization (release) of GPT associated with paracetamol
6) Confidence 0.68 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9013204 Disease Relevance 0.18 Pain Relevance 0.51
OBJECTIVE: To retrospectively analyze ALT data from McNeil osteoarthritis clinical studies involving acetaminophen in order to assess the frequency and magnitude of ALT elevations and rate of ALT resolution while patients remained on acetaminophen treatment.
Localization (rate) of ALT
7) Confidence 0.62 Published 2006 Journal Curr Med Res Opin Section Body Doc Link 17076974 Disease Relevance 0.09 Pain Relevance 0
We found that, pre-treatment with TNF-alpha resulted in approximately 50 to 60% increase in alanine aminotransferase (ALT) levels by APAP or CPZ, while interleukin-1beta (IL-1beta) or IL6 treatments showed only 15-20% increase in ALT release.
Localization (release) of ALT associated with paracetamol
8) Confidence 0.62 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20371967 Disease Relevance 1.28 Pain Relevance 1.09
The bacterial components, LPS or lipoteichoic acid (LTA) increased ALT release by approximately 35 to 38% upon drug treatment of the hepatocytes.
Localization (release) of ALT in hepatocytes
9) Confidence 0.62 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20371967 Disease Relevance 1.24 Pain Relevance 1.08
It was shown that PAR significantly increased serum ALT, AST, ALP, liver MDA levels and significantly decreased liver GSH-Px activity, when compared to the control group (Group 1).
Localization (increased) of ALT in liver
10) Confidence 0.57 Published 2009 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 18693095 Disease Relevance 0.16 Pain Relevance 0.16
Acetaminophen overdose in mice produced accumulation of Ca2+ in the nucleus (358% of control) and fragmentation of DNA (250% of control) by 6 h, with peak release of ALT occurring at 12-24 h (38,000 U/l).
Localization (release) of ALT in nucleus associated with paracetamol and overdose
11) Confidence 0.55 Published 1993 Journal FASEB J. Section Abstract Doc Link 8462787 Disease Relevance 1.17 Pain Relevance 0.51
Conversely, Bax gene knockout (Bax(-/-)) mice had 80% lower ALT activities, less DNA fragmentation, and less intermembrane protein release at 6 h.
Localization (release) of ALT associated with targeted disruption
12) Confidence 0.54 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17906064 Disease Relevance 0.71 Pain Relevance 0.61
The enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALK) were also measured.


Localization (measured) of ALT
13) Confidence 0.46 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 0.23 Pain Relevance 0
Treatment of C3Heb/FeJ mice with 300 mg/kg AAP resulted in DNA fragmentation and alanine aminotransferase (ALT) release as early as 3 h, with further increase of these parameters up to 12 h.
Localization (release) of ALT associated with paracetamol
14) Confidence 0.45 Published 2005 Journal Toxicol. Sci. Section Abstract Doc Link 15601672 Disease Relevance 0.53 Pain Relevance 0.54
APAP also caused severe centrilobular apoptosis and necrosis accompanied by leukocyte infiltration and marked elevations in the hepatic enzyme, alanine aminotransferase (ALT) released from damaged hepatocytes, and cytokine tumor necrosis factor alpha (TNF-alpha).
Localization (released) of ALT in hepatocytes associated with necrosis, paracetamol, cancer, apoptosis and cytokine
15) Confidence 0.44 Published 2008 Journal Dig. Dis. Sci. Section Abstract Doc Link 18373199 Disease Relevance 0.66 Pain Relevance 0.73
The time to normalization for ALT/AST values > 5 × ULN ranged between 4 and 132 days.
Localization (normalization) of ALT
16) Confidence 0.40 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2322990 Disease Relevance 0.08 Pain Relevance 0.04
None of the patients had complete or partial normalization of ALT or HCV RNA levels during pre-treatment or treatment period.
Spec (partial) Localization (normalization) of ALT associated with hepatitis c virus infection
17) Confidence 0.38 Published 2001 Journal Eur. J. Med. Res. Section Abstract Doc Link 11669085 Disease Relevance 1.07 Pain Relevance 0.27
Main outcome parameters were normalization of ALT and viral load.
Localization (normalization) of ALT
18) Confidence 0.38 Published 2001 Journal Eur. J. Med. Res. Section Abstract Doc Link 11669085 Disease Relevance 1.05 Pain Relevance 0.22
Mice treated with the highest dose of R. graveolens infusions presented ALT elevated to a lesser degree than AST giving an AST/ALT ratio ranging from 2.05 to 2.22.
Localization (presented) of ALT
19) Confidence 0.38 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991689 Disease Relevance 0.42 Pain Relevance 0
In contrast, injection of the anti-Fas antibody Jo-2 (positive control) caused a 28-fold increase of caspase-3 activity and severe DNA fragmentation before significant ALT release.
Localization (release) of ALT
20) Confidence 0.35 Published 1999 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 10222310 Disease Relevance 0.81 Pain Relevance 0.86

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