INT222133

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 32
Total Number 41
Disease Relevance 4.81
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cdh2) plasma membrane (Cdh2) protein complex (Cdh2)
Anatomy Link Frequency
plasma 5
mesodermal cells 4
neural 3
myocardium 2
stellate cells 2
Cdh2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 30 93.60 High High
Inflammation 78 77.76 Quite High
Hyperalgesia 3 75.12 Quite High
Eae 87 71.60 Quite High
Spinal cord 63 69.12 Quite High
Dorsal horn neuron 39 58.32 Quite High
Dorsal horn 63 52.16 Quite High
Dopamine 18 39.68 Quite Low
spinal dorsal horn 6 39.12 Quite Low
anesthesia 42 23.80 Low Low
Disease Link Frequency Relevance Heat
Adhesions 200 99.72 Very High Very High Very High
Coronary Artery Disease 163 98.52 Very High Very High Very High
Targeted Disruption 18 82.88 Quite High
INFLAMMATION 78 77.76 Quite High
Hyperalgesia 3 75.12 Quite High
Inflammatory Pain 84 71.60 Quite High
Decapitation 3 58.88 Quite High
Hypersensitivity 57 54.68 Quite High
Nociception 30 5.00 Very Low Very Low Very Low
Pain 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the separation of E- and N-cadherins was not complete at this stage, and N-cadherin was slightly expressed in the apical side of the foregut and the surface ectoderm.
Gene_expression (expressed) of N-cadherin in foregut
1) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0
Also, it was possible to clearly observe the specific coexpression of E-cadherin and N-cadherin during the formation of certain organs, and the present study enabled us to morphologically clarify cadherin switching.
Gene_expression (coexpression) of N-cadherin
2) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0.03
In the caudal region, the chorda dorsalis was inside the interstitium (asterisk) without E- and N-cadherin expressions and was independent of the neural tube (single arrow) expressing only N-cadherin and the midgut (double arrow) expressing only E-cadherin.
Gene_expression (expressing) of N-cadherin in caudal region
3) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0
On the other hand, folliculo-stellate cells which do not produce hormones began expressing only E-cadherin and stopped expressing N-cadherin [7].
Gene_expression (expressing) of N-cadherin in stellate cells
4) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0.05
While the expression of N-cadherin during organogenesis tends to be transient, N-cadherin continues to be expressed in the myocardium in adults [4].
Gene_expression (expression) of N-cadherin in myocardium
5) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0
The study showed that as hormone producing cells differentiated, they began expressing only N-cadherin and stopped expressing E-cadherin.
Gene_expression (expressing) of N-cadherin
6) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0.04
Embryonic ectodermal cells (single arrow) more dominantly expressed E-cadherin, while mesodermal cells (double arrow) more dominantly expressed N-cadherin.
Gene_expression (expressed) of N-cadherin in mesodermal cells
7) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0
While ectodermal cells more dominantly expressed E-cadherin, all cells expressed N-cadherin, and cells facing the amniotic cavity (arrowhead) strongly expressed both cadherins.
Gene_expression (expressed) of N-cadherin in amniotic cavity
8) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0
While the expression of N-cadherin during organogenesis tends to be transient, N-cadherin continues to be expressed in the myocardium in adults [4].
Gene_expression (expressed) of N-cadherin in myocardium
9) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0
During the developmental period, the expression patterns of E-cadherin and N-cadherin change spatiotemporally to regulate organogenesis.
Gene_expression (expression) of N-cadherin
10) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0.35 Pain Relevance 0
In general, E-cadherin is responsible for stable cell-to-cell adhesion, while cells expressing N-cadherin are motile.
Gene_expression (expressing) of N-cadherin associated with adhesions
11) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0.35 Pain Relevance 0
In particular, N-cadherin was expressed strongly in the medial side of multilayered and invaginated cell layers.
Gene_expression (expressed) of N-cadherin in medial
12) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0
The distribution of E-cadherin and N-cadherin in fetuses was different from that in adults [18], thus suggesting that the expression of E-cadherin and N-cadherin is dynamic.
Gene_expression (expression) of N-cadherin
13) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0.04
In the present study, it was possible to visualize the expression patterns of E-cadherin and N-cadherin during early fetal development.
Gene_expression (expression) of N-cadherin
14) Confidence 0.61 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0.04
In the caudal region, the chorda dorsalis was inside the interstitium (asterisk) without E- and N-cadherin expressions and was independent of the neural tube (single arrow) expressing only N-cadherin and the midgut (double arrow) expressing only E-cadherin.
Gene_expression (expressions) of N-cadherin in caudal region
15) Confidence 0.53 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0
Linask closely examined the expression patterns of N-cadherin in chicken embryos and documented that N-cadherin was involved with pericardial coelom formation and cardiomyocyte differentiation to from the myocardium, but not with endocardium formation [9], which supports our findings.
Spec (examined) Gene_expression (expression) of N-cadherin in embryos
16) Confidence 0.52 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0
At E10 when embryonic turning begins, in both rostral and caudal regions, the expression pattern of E-cadherin in the surface ectoderm (epidermis, single arrow) and endoderm (foregut, double arrow) and that of N-cadherin in the neuroectoderm (arrowhead) were established.
Gene_expression (expression) of N-cadherin in endoderm
17) Confidence 0.52 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2576505 Disease Relevance 0 Pain Relevance 0
After embryonic day 10, unique co-expression of E- and N-cadherin was observed in primordia, such as the bulbus cordis, otic pit, notochord, and Rathke’s pouch.
Gene_expression (expression) of N-cadherin in notochord
18) Confidence 0.47 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2576505 Disease Relevance 0.13 Pain Relevance 0
In the present study, it was possible to visualize the expression patterns of E- and N-cadherin during early fetal development, which enabled us to morphologically clarify cadherin switching.



Gene_expression (expression) of N-cadherin
19) Confidence 0.47 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2576505 Disease Relevance 0.11 Pain Relevance 0
At embryonic day 9, embryonic ectodermal cells more dominantly expressed E-cadherin, while mesodermal cells more dominantly expressed N-cadherin.
Gene_expression (expressed) of N-cadherin in mesodermal cells
20) Confidence 0.47 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2576505 Disease Relevance 0.15 Pain Relevance 0

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