INT22214

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Context Info
Confidence 0.62
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 8.42
Pain Relevance 7.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cytoplasm (Gpt)
Anatomy Link Frequency
liver 8
testis 4
Poly 4
hepatocytes 2
nucleus 2
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 91 100.00 Very High Very High Very High
Glutamate 6 97.52 Very High Very High Very High
antinociception 2 90.96 High High
Analgesic 6 90.56 High High
antagonist 3 87.80 High High
Inflammatory mediators 2 86.76 High High
Inflammation 13 82.44 Quite High
Neurotransmitter 2 77.68 Quite High
cytokine 8 73.60 Quite High
withdrawal 2 59.84 Quite High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 7 98.24 Very High Very High Very High
Overdose 2 97.34 Very High Very High Very High
Necrosis 11 96.80 Very High Very High Very High
Obesity 15 94.56 High High
Toxicity 8 94.40 High High
Stress 10 92.84 High High
Injury 9 91.48 High High
Apoptosis 9 90.72 High High
Disorder Of Lipid Metabolism 17 89.52 High High
Hepatitis 2 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Poly I-C pretreatment produced a 5-fold increase in acetaminophen-induced ALT release (P less than 0.05), which correlated with histologic evidence of centrilobular necrosis.
Positive_regulation (increase) of Localization (release) of ALT in Poly associated with necrosis and paracetamol
1) Confidence 0.62 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2262910 Disease Relevance 0.58 Pain Relevance 0.91
A combination of both nicotinamide and N-acetylcysteine (at the low dose of 12.5 mg/kg i.p. each) results in a complete protection from acetaminophen-induced release of GOT and GPT from injured liver cells. 5.
Positive_regulation (induced) of Localization (release) of GPT in liver associated with paracetamol
2) Confidence 0.59 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9013204 Disease Relevance 0.20 Pain Relevance 0.55
The acetaminophen-induced release of both GOT and GPT from injured liver cells could be inhibited in a dose-dependent manner, when mice were injected additionally either with increasing amounts (from (25 mg/kg to 100 mg/kg i.p.) of the PARP-inhibitor nicotinamide, with increasing amounts (from 25 mg/kg to 100 mg/kg i.p.) of the antioxidant N-acetylcysteine, or with increasing amounts (from 50 mg/kg to 300 mg/kg i.p.) of the amino acid L-methionine. 4.
Positive_regulation (acetaminophen-induced) of Localization (release) of GPT in liver associated with paracetamol
3) Confidence 0.49 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9013204 Disease Relevance 0.25 Pain Relevance 0.51
Poly I-C pretreatment produced a 5-fold increase in acetaminophen-induced ALT release (P less than 0.05), which correlated with histologic evidence of centrilobular necrosis.
Positive_regulation (acetaminophen-induced) of Localization (release) of ALT in Poly associated with necrosis and paracetamol
4) Confidence 0.45 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2262910 Disease Relevance 0.58 Pain Relevance 0.86
A combination of both L-methionine and N-acetylcysteine or nicotinamide (at the low dose of 12.5 mg/kg IP each) resulted also in complete protection from acetaminophen-induced release of GOT and GPT.
Positive_regulation (acetaminophen-induced) of Localization (release) of GPT associated with paracetamol
5) Confidence 0.43 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9013204 Disease Relevance 0.19 Pain Relevance 0.52
Acetaminophen overdose in mice produced accumulation of Ca2+ in the nucleus (358% of control) and fragmentation of DNA (250% of control) by 6 h, with peak release of ALT occurring at 12-24 h (38,000 U/l).
Positive_regulation (occurring) of Localization (release) of ALT in nucleus associated with paracetamol and overdose
6) Confidence 0.37 Published 1993 Journal FASEB J. Section Abstract Doc Link 8462787 Disease Relevance 1.18 Pain Relevance 0.51
We found that, pre-treatment with TNF-alpha resulted in approximately 50 to 60% increase in alanine aminotransferase (ALT) levels by APAP or CPZ, while interleukin-1beta (IL-1beta) or IL6 treatments showed only 15-20% increase in ALT release.
Positive_regulation (increase) of Localization (release) of ALT associated with paracetamol
7) Confidence 0.36 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20371967 Disease Relevance 1.28 Pain Relevance 1.10
The bacterial components, LPS or lipoteichoic acid (LTA) increased ALT release by approximately 35 to 38% upon drug treatment of the hepatocytes.
Positive_regulation (increased) of Localization (release) of ALT in hepatocytes
8) Confidence 0.36 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20371967 Disease Relevance 1.24 Pain Relevance 1.09
The enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALK) were also measured.


Positive_regulation (enzymes) of Localization (measured) of ALT
9) Confidence 0.31 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 0.23 Pain Relevance 0
In contrast, injection of the anti-Fas antibody Jo-2 (positive control) caused a 28-fold increase of caspase-3 activity and severe DNA fragmentation before significant ALT release.
Positive_regulation (caused) of Localization (release) of ALT
10) Confidence 0.23 Published 1999 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 10222310 Disease Relevance 0.83 Pain Relevance 0.88
Elevation of serum ALT and AST activities, decrease of reduced glutathione levels and histopathological liver changes were observed to the same extents in both APAP-treated groups.
Positive_regulation (Elevation) of Localization (decrease) of serum ALT in liver associated with paracetamol
11) Confidence 0.22 Published 2009 Journal Toxicology Section Abstract Doc Link 19576946 Disease Relevance 0.22 Pain Relevance 0.72
The present results showed that the activities of AST and ALT were obviously decreased by taurine supplement in testis of adult and aged rats, but were significantly increased by ?
Positive_regulation (aged) of Localization (activities) of ALT in testis
12) Confidence 0.03 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0.30 Pain Relevance 0.13
The present results showed that the activities of AST and ALT were obviously decreased by taurine supplement in testis of adult and aged rats, but were significantly increased by ?
Positive_regulation (increased) of Localization (activities) of ALT in testis
13) Confidence 0.03 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0.31 Pain Relevance 0.13
Despite higher baseline laboratory values in the simvastatin group, there were no reports of increased ALT or AST ?
Positive_regulation (increased) of Neg (no) Localization (reports) of ALT
14) Confidence 0.03 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2887787 Disease Relevance 0.71 Pain Relevance 0
METHODS: We prospectively evaluated the levels of the serum concentration of liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), and total bilirubin (TBil), in 42 morbidly obese and 40 non obese patients who were scheduled for elective abdominal surgery under sevoflurane anesthesia at the Jordan University Hospital, Amman, Jordan.
Positive_regulation (enzymes) of Localization (aspartate aminotransferase) of ALT in liver
15) Confidence 0.03 Published 2009 Journal Middle East J Anesthesiol Section Body Doc Link 19583067 Disease Relevance 0.19 Pain Relevance 0

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