INT222179

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CDC5L, TFAM) DNA binding (CDC5L, TFAM) mitochondrion (TFAM)
nucleolus (CDC5L) RNA binding (CDC5L) cell cycle (CDC5L)
Anatomy Link Frequency
B cells 1
CDC5L (Homo sapiens)
TFAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 65 94.48 High High
Inflammation 8 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Demyelination 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 69 94.48 High High
Disease 10 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Epstein-barr Virus 8 5.00 Very Low Very Low Very Low
Diabetes Mellitus 7 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using virus-transformed immortalized B cells and human whole genome bioarrays with validation using RT-qPCR, we found that in siblings with MS, genes for CXCL10, serpin B1 and FUT4 were up regulated whereas CDC5L, TNFRSF19 and HLA-DR were down regulated, among others; transcription analysis showed two intersecting clusters of transcriptional factors - the larger, governed by the upregulated transcription factor 2 (TCF2) and the smaller network regulated by the downregulated CDC5L.


CDC5L Regulation (regulated) of TCF2 in B cells associated with multiple sclerosis
1) Confidence 0.01 Published 2008 Journal BMC Med Genomics Section Abstract Doc Link PMC2227948 Disease Relevance 0.26 Pain Relevance 0.13

General Comments

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