INT222179

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.26 Pain Relevance 0.13

nucleus (CDC5L, TFAM) DNA binding (CDC5L, TFAM) mitochondrion (TFAM) nucleolus (CDC5L) RNA binding (CDC5L) cell cycle (CDC5L)

Anatomy Link Frequency B cells 1 CDC5L (Homo sapiens) TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat Multiple sclerosis 65 94.48 Inflammation 8 5.00 chemokine 5 5.00 Central nervous system 4 5.00 cytokine 4 5.00 COX2 1 5.00 Spinal cord 1 5.00 Inflammatory response 1 5.00 Demyelination 1 5.00 rheumatoid arthritis 1 5.00

Disease Link Frequency Relevance Heat Multiple Sclerosis 69 94.48 Disease 10 5.00 INFLAMMATION 9 5.00 Epstein-barr Virus 8 5.00 Diabetes Mellitus 7 5.00 Apoptosis 6 5.00 Infection 3 5.00 Death 2 5.00 Injury 2 5.00 Rheumatoid Arthritis 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Using virus-transformed immortalized B cells and human whole genome bioarrays with validation using RT-qPCR, we found that in siblings with MS, genes for CXCL10, serpin B1 and FUT4 were up regulated whereas CDC5L, TNFRSF19 and HLA-DR were down regulated, among others; transcription analysis showed two intersecting clusters of transcriptional factors - the larger, governed by the upregulated transcription factor 2 (TCF2) and the smaller network regulated by the downregulated CDC5L.

CDC5L Regulation (regulated) of TCF2 in B cells associated with multiple sclerosis

1) Confidence 0.01 Published 2008 Journal BMC Med Genomics Section Abstract Doc Link PMC2227948 Disease Relevance 0.26 Pain Relevance 0.13

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