INT222180

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.48 Pain Relevance 0.40

nucleus (HNF1B, TFAM) DNA binding (HNF1B, TFAM) mitochondrion (TFAM) nucleolus (HNF1B)

HNF1B (Homo sapiens) TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat Multiple sclerosis 65 97.12 Inflammation 8 69.48 chemokine 5 48.48 Central nervous system 4 5.00 cytokine 4 5.00 COX2 1 5.00 Spinal cord 1 5.00 Inflammatory response 1 5.00 Demyelination 1 5.00 rheumatoid arthritis 1 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 7 98.64 Multiple Sclerosis 69 97.12 Disease 10 92.80 INFLAMMATION 9 69.48 Apoptosis 6 29.04 Epstein-barr Virus 8 5.00 Infection 3 5.00 Death 2 5.00 Injury 2 5.00 Rheumatoid Arthritis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To reiterate, a link between TCF2 mutation and MODY5 has been established, while type 1 diabetics have an increased risk of MS development.

MODY5 Binding (link) of TCF2 associated with multiple sclerosis and diabetes mellitus

1) Confidence 0.01 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 1.48 Pain Relevance 0.40

General Comments

This test has worked.