INT222185

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.70
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (Ccr1, Ccl3) intracellular (Ccl3) cytoplasm (Ccl3)
signal transducer activity (Ccr1) cytosol (Ccl3) signal transduction (Ccr1)
Anatomy Link Frequency
macrophages 1
T cells 1
Ccr1 (Mus musculus)
Ccl3 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 130 99.62 Very High Very High Very High
chemokine 90 98.16 Very High Very High Very High
antagonist 8 96.24 Very High Very High Very High
cytokine 47 96.00 Very High Very High Very High
ischemia 31 92.84 High High
Inflammation 83 86.72 High High
rheumatoid arthritis 3 45.56 Quite Low
Central nervous system 8 32.88 Quite Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Arthritis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 138 99.62 Very High Very High Very High
INFLAMMATION 102 95.20 Very High Very High Very High
Reperfusion Injury 6 93.60 High High
Cv Unclassified Under Development 30 92.84 High High
Renal Disease 9 87.32 High High
Injury 167 85.40 High High
Diabetes Mellitus 14 77.88 Quite High
Apoptosis 15 76.88 Quite High
Disease 33 65.72 Quite High
Adhesions 17 59.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, CCR1 deficient mice had reduced content of the CCR1 ligands CCL3 (MIP-1alpha) and CCL5 (RANTES).
CCR1 Binding (content) of CCL3
1) Confidence 0.23 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.73 Pain Relevance 0.67
The IC50 values reported for the inhibition of receptor binding, 0.015 nM for CCL3 binding to CCR1 and 3 nM for CCL4 binding to CCR5 (11), are reflected by the ability of Evasin-1 to inhibit the chemotactic activity of these chemokines in vitro and in vivo.
CCR1 Binding (binding) of CCL3 associated with chemokine
2) Confidence 0.20 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.10 Pain Relevance 0.13
We found that TCF2 upregulates the CC chemokine receptor 1 (CCR1) a molecule expressed on macrophages and T cells; in MS plaques, numerous CCR1-positive infiltrating macrophages and microglial cells, associated with CCL3, were found [2] and CCR1 has been associated with newly infiltrating monocytes in MS lesions [32].
CCR1 Binding (associated) of CCL3 in T cells associated with chemokine and multiple sclerosis
3) Confidence 0.03 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.93 Pain Relevance 0.33
We found that TCF2 upregulates the CC chemokine receptor 1 (CCR1) a molecule expressed on macrophages and T cells; in MS plaques, numerous CCR1-positive infiltrating macrophages and microglial cells, associated with CCL3, were found [2] and CCR1 has been associated with newly infiltrating monocytes in MS lesions [32].
CCR1 Binding (associated) of CCL3 in macrophages associated with chemokine and multiple sclerosis
4) Confidence 0.01 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.93 Pain Relevance 0.33

General Comments

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