INT222212

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.17
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TFAM) plasma membrane (Cd28) nucleus (TFAM)
DNA binding (TFAM)
Anatomy Link Frequency
T-cell 1
TFAM (Homo sapiens)
Cd28 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 98.12 Very High Very High Very High
Multiple sclerosis 65 93.72 High High
chemokine 5 83.40 Quite High
rheumatoid arthritis 1 32.64 Quite Low
Central nervous system 4 19.96 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Demyelination 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 98.12 Very High Very High Very High
Multiple Sclerosis 69 96.00 Very High Very High Very High
Diabetes Mellitus 7 77.44 Quite High
Apoptosis 6 63.96 Quite High
Disease 10 52.80 Quite High
Rheumatoid Arthritis 2 32.80 Quite Low
Epstein-barr Virus 8 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, TCF2 downregulated CD28, a co-stimulatory molecule involved in T-cell stimulation and IL6R, a pro-inflammatory molecule.
TCF2 Negative_regulation (downregulated) of CD28 in T-cell associated with inflammation
1) Confidence 0.02 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 1.17 Pain Relevance 0.39

General Comments

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