INT222212

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.17 Pain Relevance 0.39

mitochondrion (TFAM) plasma membrane (Cd28) nucleus (TFAM) DNA binding (TFAM)

Anatomy Link Frequency T-cell 1 TFAM (Homo sapiens) Cd28 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 8 98.12 Multiple sclerosis 65 93.72 chemokine 5 83.40 rheumatoid arthritis 1 32.64 Central nervous system 4 19.96 cytokine 4 5.00 COX2 1 5.00 Spinal cord 1 5.00 Inflammatory response 1 5.00 Demyelination 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 9 98.12 Multiple Sclerosis 69 96.00 Diabetes Mellitus 7 77.44 Apoptosis 6 63.96 Disease 10 52.80 Rheumatoid Arthritis 2 32.80 Epstein-barr Virus 8 5.00 Infection 3 5.00 Death 2 5.00 Injury 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, TCF2 downregulated CD28, a co-stimulatory molecule involved in T-cell stimulation and IL6R, a pro-inflammatory molecule.

TCF2 Negative_regulation (downregulated) of CD28 in T-cell associated with inflammation

1) Confidence 0.02 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 1.17 Pain Relevance 0.39

General Comments

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