INT222213

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 3.96 Pain Relevance 1.40

signal transduction (Ccr1) mitochondrion (TFAM) plasma membrane (Ccr1) nucleus (TFAM) DNA binding (TFAM) cell-cell signaling (Ccr1)

Anatomy Link Frequency T cells 6 macrophages 2 TFAM (Homo sapiens) Ccr1 (Mus musculus)

Pain Link Frequency Relevance Heat Multiple sclerosis 260 100.00 chemokine 20 100.00 Inflammation 32 79.20 rheumatoid arthritis 4 50.56 Central nervous system 16 37.88 cytokine 16 5.00 COX2 4 5.00 Spinal cord 4 5.00 Inflammatory response 4 5.00 Demyelination 4 5.00

Disease Link Frequency Relevance Heat Multiple Sclerosis 276 100.00 Diabetes Mellitus 28 82.88 Apoptosis 24 81.88 INFLAMMATION 36 79.20 Disease 40 70.72 Rheumatoid Arthritis 8 50.72 Epstein-barr Virus 32 5.00 Infection 12 5.00 Death 8 5.00 Injury 8 5.00

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Mutation

Event

Anatomy

Negation

Speculation

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Disease term

We found that TCF2 upregulates the CC chemokine receptor 1 (CCR1) a molecule expressed on macrophages and T cells; in MS plaques, numerous CCR1-positive infiltrating macrophages and microglial cells, associated with CCL3, were found [2] and CCR1 has been associated with newly infiltrating monocytes in MS lesions [32].

TCF2 Positive_regulation (upregulates) of Gene_expression (expressed) of CCR1 in T cells associated with chemokine and multiple sclerosis

1) Confidence 0.02 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.95 Pain Relevance 0.35

We found that TCF2 upregulates the CC chemokine receptor 1 (CCR1) a molecule expressed on macrophages and T cells; in MS plaques, numerous CCR1-positive infiltrating macrophages and microglial cells, associated with CCL3, were found [2] and CCR1 has been associated with newly infiltrating monocytes in MS lesions [32].

TCF2 Positive_regulation (upregulates) of Gene_expression (expressed) of CCR1 in T cells associated with chemokine and multiple sclerosis

2) Confidence 0.02 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 1.03 Pain Relevance 0.35

We found that TCF2 upregulates the CC chemokine receptor 1 (CCR1) a molecule expressed on macrophages and T cells; in MS plaques, numerous CCR1-positive infiltrating macrophages and microglial cells, associated with CCL3, were found [2] and CCR1 has been associated with newly infiltrating monocytes in MS lesions [32].

TCF2 Positive_regulation (upregulates) of in macrophages Gene_expression (expressed) of CCR1 in T cells associated with chemokine and multiple sclerosis

3) Confidence 0.01 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.95 Pain Relevance 0.35

We found that TCF2 upregulates the CC chemokine receptor 1 (CCR1) a molecule expressed on macrophages and T cells; in MS plaques, numerous CCR1-positive infiltrating macrophages and microglial cells, associated with CCL3, were found [2] and CCR1 has been associated with newly infiltrating monocytes in MS lesions [32].

TCF2 Positive_regulation (upregulates) of in macrophages Gene_expression (expressed) of CCR1 in T cells associated with chemokine and multiple sclerosis

4) Confidence 0.01 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 1.03 Pain Relevance 0.35

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