INT222226

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.69
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) plasma membrane (Ccr2) cytoplasm (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
neurons 1
nerve 1
astrocytes 1
Ccr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 85 100.00 Very High Very High Very High
Neuropathic pain 63 99.76 Very High Very High Very High
Hyperalgesia 32 99.48 Very High Very High Very High
chemokine 225 98.12 Very High Very High Very High
Stimulus evoked pain 5 94.88 High High
Demyelination 54 94.12 High High
Cholecystokinin 1 93.04 High High
Neuropeptide 3 91.04 High High
dorsal root ganglion 84 89.24 High High
Peripheral nerve injury 9 86.68 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 93 99.76 Very High Very High Very High
Hyperalgesia 57 99.48 Very High Very High Very High
Injury 114 98.40 Very High Very High Very High
Status Epilepticus 212 97.56 Very High Very High Very High
Hypersensitivity 14 94.88 High High
Nervous System Injury 50 94.36 High High
Pain 43 94.20 High High
Demyelinating Disease 57 94.12 High High
Rheumatoid Arthritis 31 91.68 High High
Ganglion Cysts 85 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The selectivity of AZ889 was used to confirm that the reversal of heat and mechanical hyperalgesia is caused by a selective block of the CCR2 receptor.
Negative_regulation (block) of CCR2 receptor associated with hyperalgesia
1) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.48 Pain Relevance 0.62
The particular effectiveness of CCR2 block could be due to the fact that upregulation of chemokines can be bilaterally expressed in different populations of sensory neurons following nerve injury, as is this case of cholecystokinin vasoactive inhibitory peptide and neuropeptide Y [43,47].
Negative_regulation (block) of CCR2 in nerve associated with chemokine, nervous system injury, neuropeptide and cholecystokinin
2) Confidence 0.38 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.96 Pain Relevance 1.12
A CCR2 receptor antagonist and its inactive enantiomer, both gifts of Eli Lilly and Co, were employed in this study [24].
Negative_regulation (antagonist) of CCR2 receptor associated with antagonist
3) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.13 Pain Relevance 0.20
Furthermore, a study by Abbadie and colleagues [34] demonstrated that mice lacking the CCR2 receptor lack neuropathic pain impairment after injury.
Negative_regulation (lacking) of CCR2 receptor associated with injury and neuropathic pain
4) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.21 Pain Relevance 0.57
In the present study, MCP-1 immunoreactivity was detected in microglia, and CCR2 immunoreactivity was colocalized with MIP-2 immunoreactivity in astrocytes and neurons after SE.
Negative_regulation (colocalized) of CCR2 in neurons associated with status epilepticus
5) Confidence 0.30 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.46 Pain Relevance 0.08
In the present study, MCP-1 immunoreactivity was detected in microglia, and CCR2 immunoreactivity was colocalized with MIP-2 immunoreactivity in astrocytes and neurons after SE.
Negative_regulation (colocalized) of CCR2 in astrocytes associated with status epilepticus
6) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.46 Pain Relevance 0.08

General Comments

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