INT222227

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Context Info
Confidence 0.64
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.61
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
neurons 2
endothelial cells 1
vesicles 1
HGF 1
Cxcl12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 258 98.96 Very High Very High Very High
qutenza 17 98.00 Very High Very High Very High
Demyelination 96 91.48 High High
glial activation 4 86.12 High High
Dorsal horn 6 84.00 Quite High
Spinal cord 16 83.52 Quite High
Peripheral nervous system 2 79.04 Quite High
antagonist 46 78.96 Quite High
Neuropathic pain 44 76.72 Quite High
ischemia 8 74.80 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 22 92.56 High High
Demyelinating Disease 99 91.48 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 23 85.28 High High
Disease 8 80.00 Quite High
Injury 61 79.56 Quite High
Neuropathic Pain 50 76.72 Quite High
Cv Unclassified Under Development 8 74.80 Quite High
Rheumatoid Arthritis 32 69.60 Quite High
Neuropathy 17 60.36 Quite High
Nociception 35 56.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulated CXCR4 expression, however, is primarily restricted to neurons making them a potential target for the release of SDF-1 from glia.
Localization (release) of SDF-1 in neurons
1) Confidence 0.64 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.60 Pain Relevance 0.50
We have observed that chemokines expressed by DRG neurons, including MCP1, IP10 and SDF1, can be packaged into secretory vesicles and released upon depolarization [9].
Localization (released) of SDF1 in vesicles associated with chemokine
2) Confidence 0.60 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.28 Pain Relevance 0.58
Furthermore, most of the cells responding to MCP1 and SDF1 application were neurons, based on their response profile to capsaicin, high K+ and ATP (Table 3).
Localization (application) of SDF1 in neurons associated with qutenza
3) Confidence 0.46 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.42 Pain Relevance 0.44
Although the aim of this work was not the identification of the molecular effectors responsible for the angiogenic properties of EPC-CM, we have confirmed that EPC release key angiogenic molecules such as Angiogenin, HGF, IL-8, PDGF, SDF-1 and VEGF in culture.
Localization (release) of SDF-1 in HGF
4) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.23 Pain Relevance 0.03
Preclinical studies have described that EPC secretion of factors involved in the regulation of stem cell recruitment and in vascular growth and remodeling (such as SDF-1, VEGF, HGF and MMP-9) [5], [17] support the function of mature endothelial cells in vitro and tissue regeneration in a variety of animal models [21], [22].
Localization (secretion) of SDF-1 in endothelial cells
5) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

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