INT22223

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 5.87
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xdh) oxidoreductase activity (Xdh) extracellular region (Xdh)
peroxisome (Xdh) cytoplasm (Xdh)
Anatomy Link Frequency
muscle 4
erythrocytes 3
blood 1
plasma 1
skeletal muscle 1
Xdh (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 28 99.98 Very High Very High Very High
Paracetamol 16 99.88 Very High Very High Very High
Inflammation 7 98.60 Very High Very High Very High
depression 73 96.72 Very High Very High Very High
anesthesia 18 95.60 Very High Very High Very High
Arthritis 4 78.80 Quite High
cytokine 17 76.04 Quite High
COX-2 inhibitor 2 69.92 Quite High
Inflammatory marker 2 65.88 Quite High
cINOD 6 64.80 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 17 99.58 Very High Very High Very High
Disease 8 99.44 Very High Very High Very High
Death 13 99.38 Very High Very High Very High
INFLAMMATION 13 98.60 Very High Very High Very High
Injury 18 97.80 Very High Very High Very High
Rheumatic Diseases 1 97.48 Very High Very High Very High
Stress 20 97.28 Very High Very High Very High
Depression 75 96.72 Very High Very High Very High
Cardiovascular Disease 11 94.32 High High
Hepatotoxicity 3 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we demonstrated elevated levels of xanthine oxidase in serum of patients with various inflammatory and autoimmune rheumatic diseases.
Positive_regulation (elevated) of xanthine oxidase associated with inflammation and rheumatic diseases
1) Confidence 0.67 Published 1994 Journal Inflammation Section Abstract Doc Link 7843803 Disease Relevance 0.49 Pain Relevance 0.20
Acetaminophen also caused a long-lasting 50% reduction of the hepatic ATP content, an irreversible loss of hepatic xanthine dehydrogenase activity and a transient increase of the xanthine oxidase activity.
Positive_regulation (increase) of xanthine oxidase associated with paracetamol
2) Confidence 0.63 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2262912 Disease Relevance 0.24 Pain Relevance 0.48
Increased XOR activity in the absence of NO attenuation is associated with the pathophysiology of cardiac dysfunction [34],[39],[40] and inhibition of XOR using allopurinal has previously been shown beneficial for maintaining normal cardiac and vascular hemodynamics [39].
Positive_regulation (Increased) of XOR
3) Confidence 0.56 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 0.23 Pain Relevance 0
Acetaminophen also promoted the conversion of the enzyme xanthine dehydrogenase to the oxidase form, and pretreatment of mice with allopurinol, an inhibitor of xanthine oxidase, significantly decreased acetaminophen-mediated hepatotoxicity.
Positive_regulation (promoted) of xanthine dehydrogenase associated with paracetamol and hepatotoxicity
4) Confidence 0.36 Published 1990 Journal J. Biol. Chem. Section Abstract Doc Link 2303440 Disease Relevance 0.09 Pain Relevance 0.58
We tested the hypotheses that 1) after an isometric contraction protocol, xanthine oxidase (XO) activity is a source of superoxide anion in the extracellular space of skeletal muscle and 2) the increase in XO-derived extracellular superoxide anion during contractions affects skeletal muscle contractile function.
Positive_regulation (increase) of XO-derived in skeletal muscle
5) Confidence 0.29 Published 2010 Journal American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Section Abstract Doc Link PMC2806206 Disease Relevance 0 Pain Relevance 0
The enhanced XO activity can be attenuated by chronic allopurinol treatment.
Positive_regulation (enhanced) of XO
6) Confidence 0.23 Published 2003 Journal Microvasc. Res. Section Abstract Doc Link 12826072 Disease Relevance 0.30 Pain Relevance 0.35
These results suggest that dexamethasone induces an elevated level of XO activity in the cremaster muscle.
Positive_regulation (induces) of XO in muscle associated with dexamethasone
7) Confidence 0.23 Published 2003 Journal Microvasc. Res. Section Abstract Doc Link 12826072 Disease Relevance 0.36 Pain Relevance 0.36
Hellsten et al. (18) first showed that XO is an important source of ROS generation during exercise and demonstrated that a chronic exercise protocol increased XO activity in human muscle.
Positive_regulation (increased) of XO in muscle
8) Confidence 0.22 Published 2010 Journal American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Section Body Doc Link PMC2806206 Disease Relevance 0.05 Pain Relevance 0.03
Among the biochemical parameters, plasma xanthine oxidase (XO) activity was found to be more elevated in the cisplatin group than the saline group (p<0.05).
Positive_regulation (elevated) of XO in plasma
9) Confidence 0.19 Published 2004 Journal J Chemother Section Abstract Doc Link 15332714 Disease Relevance 0 Pain Relevance 0.08
Biochemical studies noted an increased XO activity following cisplatin administration ( P <0.007).
Positive_regulation (increased) of XO
10) Confidence 0.16 Published 2005 Journal Eur Arch Otorhinolaryngol Section Abstract Doc Link 15742177 Disease Relevance 0.12 Pain Relevance 0.07
These results suggest that dexamethasone induces an elevated level of XO activity in the cremaster muscle.
Positive_regulation (elevated) of XO in muscle associated with dexamethasone
11) Confidence 0.16 Published 2003 Journal Microvasc. Res. Section Abstract Doc Link 12826072 Disease Relevance 0.36 Pain Relevance 0.36
The mean blood pressure and XO levels in cremaster muscle were significantly increased in the dexamethasone-treated rats compared with controls.
Positive_regulation (increased) of XO in muscle associated with dexamethasone
12) Confidence 0.14 Published 2003 Journal Microvasc. Res. Section Abstract Doc Link 12826072 Disease Relevance 0.66 Pain Relevance 0.33
Prior to death, blood samples were drawn for measurement of superoxide dismutase, xanthine oxidase (XO), malondialdehyde and nitric oxide.
Positive_regulation (measurement) of XO in blood associated with death
13) Confidence 0.13 Published 2005 Journal Eur Arch Otorhinolaryngol Section Abstract Doc Link 15742177 Disease Relevance 0.18 Pain Relevance 0.10
The increase in XO activity may render the erythrocyte membranes sensitive to oxidant stress, and the decrease in NOS activity in the erythrocytes may increase cardiovascular disease risk via reduced endothelial relaxation.
Positive_regulation (increase) of XO in erythrocytes associated with stress and cardiovascular disease
14) Confidence 0.03 Published 2008 Journal Nutr Res Section Abstract Doc Link 19083410 Disease Relevance 0.36 Pain Relevance 0.07
In conclusion, our results suggest that cholesterol feeding causes an increase in XO activity and a decrease in NOS activity in the erythrocytes from rats.
Positive_regulation (increase) of XO in erythrocytes
15) Confidence 0.03 Published 2008 Journal Nutr Res Section Abstract Doc Link 19083410 Disease Relevance 0.26 Pain Relevance 0.07
We observed that serum total cholesterol levels, erythrocyte XO activities, and sensitivity to oxidation values significantly increased in group 2 (cholesterol fed) compared with the control group (group 1).
Positive_regulation (increased) of XO in erythrocyte associated with disorder of lipid metabolism
16) Confidence 0.02 Published 2008 Journal Nutr Res Section Abstract Doc Link 19083410 Disease Relevance 0.27 Pain Relevance 0.08
Furthermore, both compounds reduced SOD activity and increased XO activity in gastric mucosa.
Positive_regulation (increased) of XO
17) Confidence 0.02 Published 2002 Journal Free Radic. Res. Section Abstract Doc Link 12180128 Disease Relevance 0.59 Pain Relevance 0.26
During depression there are increased levels of radical nitrogen species (RNS) and reactive oxygen species (ROS) such as peroxide, and the activities of pro-oxidant enzymes such as xanthine oxidase (XO) are also increased, nitric oxide (NO) levels are changed and there are indications of oxidative and nitrosative stress (O&NS) damage to fatty acids and DNA [39].
Positive_regulation (increased) of xanthine oxidase associated with stress and depression
18) Confidence 0.02 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2994859 Disease Relevance 1.29 Pain Relevance 0.44

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox