INT222230

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 17
Disease Relevance 5.26
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
bladder 6
hearts 6
sciatic nerve 2
blood vessel 2
neurons 2
Cxcl12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 57 100.00 Very High Very High Very High
chemokine 468 99.98 Very High Very High Very High
qutenza 29 98.28 Very High Very High Very High
Demyelination 145 93.52 High High
dorsal root ganglion 96 88.20 High High
Inflammation 112 87.72 High High
cytokine 80 83.28 Quite High
Neuropathic pain 72 78.76 Quite High
ischemia 8 78.28 Quite High
Peripheral nerve injury 12 72.00 Quite High
Disease Link Frequency Relevance Heat
Atherosclerotic Plaque 1 100.00 Very High Very High Very High
Cancer 154 99.24 Very High Very High Very High
Coronary Artery Disease 1 98.08 Very High Very High Very High
Nervous System Injury 100 96.36 Very High Very High Very High
Demyelinating Disease 150 93.52 High High
Myocardial Infarction 355 92.32 High High
Aids-related Complex 5 88.76 High High
Ganglion Cysts 99 88.20 High High
INFLAMMATION 128 87.72 High High
Infarction 218 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The numbers of c-Kit+ and CXCR4+ cells were significantly higher in the infarct areas with overexpression of SDF-1?
Positive_regulation (overexpression) of Gene_expression (overexpression) of SDF-1
1) Confidence 0.59 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.68 Pain Relevance 0
Overexpressing SDF-1 contributed to preservation of ±dp/dtmax, LVSP and LVEDP in infarct hearts.
Positive_regulation (Overexpressing) of Gene_expression (Overexpressing) of SDF-1 in hearts
2) Confidence 0.59 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.07 Pain Relevance 0.10
Furthermore, overexpressing SDF-1 could inhibit LV remodeling, augment or preserve the myocardial elasticity, improve heart function and reduce the expression of extracellular matrix genes (eg: Collagen, et al.).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SDF-1 in extracellular matrix
3) Confidence 0.59 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0 Pain Relevance 0.06
The angiogenic effect of SDF-1 overexpression was measured in terms of blood vessel density in the infarct regions after immunostaining for vWF-VIII (Fig. 3e–h).
Positive_regulation (overexpression) of Gene_expression (overexpression) of SDF-1 in blood vessel
4) Confidence 0.59 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.36 Pain Relevance 0
And SDF-1 overexpressing hearts were less dilated and a combination of less dilatation and a trend toward less paradoxical systolic bulging probably led to the improved ventricular pressure.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of SDF-1 in hearts
5) Confidence 0.59 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.06 Pain Relevance 0.06
For SDF-1 immunohistochemistry, frozen bladder sections were exposed to SDF-1 antisera (rabbit polyclonal; Torrey Pines Biolabs, Houston, TX, USA; TP201;1?
Positive_regulation (exposed) of Gene_expression (immunohistochemistry) of SDF-1 in bladder
6) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.06 Pain Relevance 0
Cyclosphosphamide increased bladder SDF-1 levels
Positive_regulation (increased) of Gene_expression (levels) of SDF-1 in bladder
7) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
For SDF-1 immunohistochemistry, frozen bladder sections were exposed to SDF-1 antisera (rabbit polyclonal; Torrey Pines Biolabs, Houston, TX, USA; TP201;1?
Positive_regulation (exposed) of Gene_expression (antisera) of SDF-1 in bladder
8) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.05 Pain Relevance 0
The number of c-Kit+ stem cells, and gene expression of SDF-1, VEGF and bFGF were obviously increased, which was associated with reduced infarct size, thicker left ventricle wall, greater vascular density and cardiocytes density in infarcted hearts of AdV-SDF-1 group.
Positive_regulation (increased) of Gene_expression (expression) of SDF-1 in hearts
9) Confidence 0.43 Published 2009 Journal Mol Biol Rep Section Abstract Doc Link PMC2831180 Disease Relevance 0.46 Pain Relevance 0
For all experiments, MCP-1, SDF1, RANTES and IP10 were added to the cells in random order, after which capsaicin, high K+ (50 K) and ATP were added.
Positive_regulation (experiments) of Gene_expression (added) of SDF1 associated with qutenza
10) Confidence 0.40 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.09 Pain Relevance 0.27
We have observed that chemokines expressed by DRG neurons, including MCP1, IP10 and SDF1, can be packaged into secretory vesicles and released upon depolarization [9].
Positive_regulation (packaged) of Gene_expression (expressed) of SDF1 in vesicles associated with chemokine
11) Confidence 0.40 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.29 Pain Relevance 0.58
Using in situ hybridization we examined lumbar DRG associated with the injured sciatic nerve for SDF-1 expression at POD14.
Positive_regulation (sciatic nerve) of Gene_expression (expression) of SDF-1 in sciatic nerve associated with sciatic nerve
12) Confidence 0.40 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.59 Pain Relevance 0.09
However, the effect of intrinsic SDF-1 upregulated expression is, transient and insufficient for cardiac repair [6].Therefore, forced expression of SDF-1?
Positive_regulation (forced) of Gene_expression (expression) of SDF-1
13) Confidence 0.40 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.38 Pain Relevance 0.04
However, when both treatments were combined, rather than observing the increased expression of either MCP1/CCR2 or SDF1/CXCR4, both chemokine signaling systems were upregulated and this was observed to occur mostly in neurons.
Positive_regulation (increased) of Gene_expression (expression) of SDF1 in neurons associated with chemokine
14) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.86 Pain Relevance 0.39
-induced protein 10 (IP-10/CXCL10), MCP1 and SDF1 were added to the cells in random order, after which capsaicin, high K+ (50 K) and ATP were added.
Positive_regulation (induced) of Gene_expression (added) of SDF1 associated with qutenza
15) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.15 Pain Relevance 0.34
Previous studies have shown the expression of SDF-1 in atherosclerotic plaques, its upregulation in the heart early after MI as well as the increase in neovascularization following its exogenous expression [18].
Positive_regulation (increase) of Gene_expression (expression) of SDF-1 in plaques associated with atherosclerotic plaque
16) Confidence 0.23 Published 2007 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570564 Disease Relevance 0.49 Pain Relevance 0.07
The increased expression of VEGF, SDF-1 and HIF-1?
Positive_regulation (increased) of Gene_expression (expression) of SDF-1
17) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806917 Disease Relevance 0.68 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox