INT222233

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 42
Total Number 65
Disease Relevance 32.64
Pain Relevance 10.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
bladder 8
hearts 7
myocardium 5
peripheral nerves 3
neuronal 2
Cxcl12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 1617 100.00 Very High Very High Very High
Sciatic nerve 189 99.90 Very High Very High Very High
Demyelination 441 99.76 Very High Very High Very High
dorsal root ganglion 426 99.44 Very High Very High Very High
Pain 189 99.00 Very High Very High Very High
hyperexcitability 58 98.64 Very High Very High Very High
qutenza 108 98.28 Very High Very High Very High
glial activation 18 98.00 Very High Very High Very High
Dorsal horn 36 95.88 Very High Very High Very High
Inflammation 450 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Atherosclerotic Plaque 2 99.84 Very High Very High Very High
Myocardial Infarction 1210 99.76 Very High Very High Very High
Cancer 1205 99.76 Very High Very High Very High
Demyelinating Disease 459 99.76 Very High Very High Very High
Ganglion Cysts 435 99.44 Very High Very High Very High
Infarction 746 99.36 Very High Very High Very High
Pain 315 99.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 198 98.68 Very High Very High Very High
Cystitis 204 98.44 Very High Very High Very High
Coronary Artery Disease 2 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results show that both CXCR4 and SDF-1 are constitutively expressed in normal rat bladder and upregulated during CYP-induced cystitis.
Gene_expression (expressed) of SDF-1 in bladder associated with cystitis
1) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.73 Pain Relevance 0.15
Bladder MIF and SDF-1 levels are expressed normalized to protein amount (BCA, Thermo Scientific) present in the samples.
Gene_expression (expressed) of SDF-1 in Bladder
2) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
CXCR4 and SDF-1 are also expressed in human intestinal epithelial cells where recent evidence indicates it participates in epithelial repair following injury and maintaining mucosal barrier integrity [31], [32].
Gene_expression (expressed) of SDF-1 in epithelial cells associated with injury
3) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.71 Pain Relevance 0.31
Recently, down-regulation of SDF-1 mRNA expression in the bladder (and other pelvic viscera) was reported afer vaginal distension [29].
Gene_expression (expression) of SDF-1 mRNA in bladder
4) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.21 Pain Relevance 0.13
The numbers of c-Kit+ and CXCR4+ cells were significantly higher in the infarct areas with overexpression of SDF-1?
Gene_expression (overexpression) of SDF-1
5) Confidence 0.66 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.68 Pain Relevance 0
The number of c-Kit+ stem cells, and gene expression of SDF-1, VEGF and bFGF were obviously increased, which was associated with reduced infarct size, thicker left ventricle wall, greater vascular density and cardiocytes density in infarcted hearts of AdV-SDF-1 group.
Gene_expression (expression) of SDF-1 in hearts
6) Confidence 0.66 Published 2009 Journal Mol Biol Rep Section Abstract Doc Link PMC2831180 Disease Relevance 0.46 Pain Relevance 0
Overexpressing SDF-1 contributed to preservation of ±dp/dtmax, LVSP and LVEDP in infarct hearts.
Gene_expression (Overexpressing) of SDF-1 in hearts
7) Confidence 0.66 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.07 Pain Relevance 0.10
Furthermore, overexpressing SDF-1 could inhibit LV remodeling, augment or preserve the myocardial elasticity, improve heart function and reduce the expression of extracellular matrix genes (eg: Collagen, et al.).
Gene_expression (overexpressing) of SDF-1 in extracellular matrix
8) Confidence 0.66 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0 Pain Relevance 0.06
The angiogenic effect of SDF-1 overexpression was measured in terms of blood vessel density in the infarct regions after immunostaining for vWF-VIII (Fig. 3e–h).
Gene_expression (overexpression) of SDF-1 in blood vessel
9) Confidence 0.66 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.36 Pain Relevance 0
And SDF-1 overexpressing hearts were less dilated and a combination of less dilatation and a trend toward less paradoxical systolic bulging probably led to the improved ventricular pressure.
Gene_expression (overexpressing) of SDF-1 in hearts
10) Confidence 0.66 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.06 Pain Relevance 0.06
It has been reported that Schwann cells in the peripheral nerve express SDF-1 and that its expression increases moderately after nerve injury [3,29,33].
Gene_expression (express) of SDF-1 in peripheral nerve associated with nervous system injury
11) Confidence 0.62 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.67 Pain Relevance 0.07
We have observed that chemokines expressed by DRG neurons, including MCP1, IP10 and SDF1, can be packaged into secretory vesicles and released upon depolarization [9].
Gene_expression (expressed) of SDF1 in vesicles associated with chemokine
12) Confidence 0.62 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.29 Pain Relevance 0.58
The chemokine SDF-1/CXCL12 and its receptor CXCR4 are constitutively expressed by peripheral nerves [3,27-29] and chemokines that activate CCR5 and CXCR3 receptors, such as RANTES and IP-10, are synthesized in association with neuroinflammatory responses [16,30].
Gene_expression (expressed) of CXCL12 in peripheral nerves associated with chemokine
13) Confidence 0.62 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.33 Pain Relevance 0.56
Using in situ hybridization we examined lumbar DRG associated with the injured sciatic nerve for SDF-1 expression at POD14.
Gene_expression (expression) of SDF-1 in sciatic nerve associated with sciatic nerve
14) Confidence 0.62 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.59 Pain Relevance 0.09
The chemokine SDF-1/CXCL12 and its receptor CXCR4 are constitutively expressed by peripheral nerves [3,27-29] and chemokines that activate CCR5 and CXCR3 receptors, such as RANTES and IP-10, are synthesized in association with neuroinflammatory responses [16,30].
Gene_expression (expressed) of SDF-1 in peripheral nerves associated with chemokine
15) Confidence 0.62 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.33 Pain Relevance 0.56
Cyclosphosphamide increased bladder SDF-1 levels
Gene_expression (levels) of SDF-1 in bladder
16) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
In this model then, chemokines and chemokine receptors (and particularly CXCR4/SDF-1) may represent an autocrine/paracrine loop that helps maintain mucosal barrier integrity and repair as well as regulating mucosal pathogenesis (including chronic inflammation as seen inflammatory bowel disease and progression to colon cancer) [33] .
Gene_expression (/) of SDF-1 in bowel associated with chemokine, inflammation and colon cancer
17) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.92 Pain Relevance 0.39
However, SDF-1 immunostaining was not detected in bladder (Fig. 4C) or spleen (not shown).


Gene_expression (immunostaining) of SDF-1 in spleen
18) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
For SDF-1 immunohistochemistry, frozen bladder sections were exposed to SDF-1 antisera (rabbit polyclonal; Torrey Pines Biolabs, Houston, TX, USA; TP201;1?
Gene_expression (immunohistochemistry) of SDF-1 in bladder
19) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.06 Pain Relevance 0
For SDF-1 immunohistochemistry, frozen bladder sections were exposed to SDF-1 antisera (rabbit polyclonal; Torrey Pines Biolabs, Houston, TX, USA; TP201;1?
Gene_expression (antisera) of SDF-1 in bladder
20) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.05 Pain Relevance 0

General Comments

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