INT222235

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.32
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) plasma membrane (Ccr2) cytoplasm (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
neurons 3
astrocytes 2
neuronal 1
Ccr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 187 98.72 Very High Very High Very High
Inflammation 42 97.08 Very High Very High Very High
Spinal cord 45 97.04 Very High Very High Very High
dorsal root ganglion 42 94.16 High High
Demyelination 52 84.04 Quite High
Hyperalgesia 32 80.80 Quite High
Analgesic 8 78.88 Quite High
antagonist 79 75.56 Quite High
nociceptor 11 75.36 Quite High
c fibre 7 74.88 Quite High
Disease Link Frequency Relevance Heat
Status Epilepticus 424 98.56 Very High Very High Very High
INFLAMMATION 55 97.08 Very High Very High Very High
Nervous System Injury 42 96.68 Very High Very High Very High
Ganglion Cysts 43 94.16 High High
Neuropathic Pain 77 89.40 High High
Demyelinating Disease 54 84.04 Quite High
Injury 87 82.08 Quite High
Hyperalgesia 52 80.80 Quite High
Pain 38 70.48 Quite High
Rheumatoid Arthritis 21 66.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite this observation, our results could indicate either the presence of CCR2 on both cell types or that CCL2-evoked neuronal activation is indirectly mediated following glial CCR2 excitation and release of a gliotransmitter onto neurons.
Localization (presence) of CCR2 in neuronal
1) Confidence 0.73 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.38 Pain Relevance 0.39
Hence, the importance of MCP1/CCR2 signaling following administration of a T-tropic gp120/hCD4 may involve a hierarchy of effects wherein initial interactions with CXCR4 lead to downstream changes in MCP1/CCR2 functional signaling.
Localization (importance) of CCR2
2) Confidence 0.65 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.65 Pain Relevance 0.28
Relatively few (<6%) CCR2-positive neurons were colocalized with IB4-binding neurons ipsilateral (Fig. 2F and Fig. 3) or contralateral to the nerve injury at POD 14 (Fig. 3).
Localization (colocalized) of CCR2 in neurons associated with nervous system injury
3) Confidence 0.58 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.32 Pain Relevance 0.45
At 2-3 days after SE, both astrocytes and neurons showed MIP-2 immunoreactivity, which were colocalized with CCR2 (receptor for MCP-1) immunoreactivity (Figures 8A2-3 and 8E1-3).
Localization (receptor) of CCR2 in neurons associated with status epilepticus
4) Confidence 0.53 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.99 Pain Relevance 0
At 2-3 days after SE, both astrocytes and neurons showed MIP-2 immunoreactivity, which were colocalized with CCR2 (receptor for MCP-1) immunoreactivity (Figures 8A2-3 and 8E1-3).
Localization (colocalized) of CCR2 in neurons associated with status epilepticus
5) Confidence 0.53 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.99 Pain Relevance 0
At 2-3 days after SE, both astrocytes and neurons showed MIP-2 immunoreactivity, which were colocalized with CCR2 (receptor for MCP-1) immunoreactivity (Figures 8A2-3 and 8E1-3).
Localization (colocalized) of CCR2 in astrocytes associated with status epilepticus
6) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.99 Pain Relevance 0
At 2-3 days after SE, both astrocytes and neurons showed MIP-2 immunoreactivity, which were colocalized with CCR2 (receptor for MCP-1) immunoreactivity (Figures 8A2-3 and 8E1-3).
Localization (receptor) of CCR2 in astrocytes associated with status epilepticus
7) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.99 Pain Relevance 0

General Comments

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