INT222237

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.39
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) plasma membrane (Ccr2) cytoplasm (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
spinal 4
peripheral nerve 2
Ccr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 256 100.00 Very High Very High Very High
dorsal root ganglion 42 99.68 Very High Very High Very High
spinal stenosis 6 99.20 Very High Very High Very High
Peripheral nerve injury 7 99.12 Very High Very High Very High
Lasting pain 18 95.00 High High
Neuropathic pain 44 90.64 High High
nociceptor 17 85.28 High High
c fibre 10 78.40 Quite High
Eae 10 77.88 Quite High
Hyperalgesia 28 74.68 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 44 99.68 Very High Very High Very High
Spinal Stenosis 6 99.20 Very High Very High Very High
Nervous System Injury 64 98.68 Very High Very High Very High
Pain 57 95.00 High High
Rheumatoid Arthritis 32 93.52 High High
Neuropathic Pain 50 90.64 High High
Injury 61 89.28 High High
Syndrome 5 89.28 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 23 87.52 High High
Inflammatory Pain 6 77.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A more recent publication provides direct evidence that CCR2 expression is limited to the DRG following peripheral nerve injury [38].
Negative_regulation (limited) of Gene_expression (expression) of CCR2 in peripheral nerve associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
1) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.93 Pain Relevance 0.50
Indeed, we previously demonstrated that in a rodent model of spinal stenosis, chronic compression of the DRG (CCD), produced a delayed but chronic expression of both the chemokine receptor CCR2 and its ligand, the chemokine MCP-1/CCL2 in lumbar DRGs [8].
Negative_regulation (produced) of Gene_expression (expression) of chemokine receptor CCR2 in spinal associated with chemokine and spinal stenosis
2) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 1.23 Pain Relevance 1.21
Indeed, we previously demonstrated that in a rodent model of spinal stenosis, chronic compression of the DRG (CCD), produced a delayed but chronic expression of both the chemokine receptor CCR2 and its ligand, the chemokine MCP-1/CCL2 in lumbar DRGs [8].
Negative_regulation (delayed) of Gene_expression (expression) of chemokine receptor CCR2 in spinal associated with chemokine and spinal stenosis
3) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 1.23 Pain Relevance 1.20

General Comments

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