INT22224

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Context Info
Confidence 0.42
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.87
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xdh) oxidoreductase activity (Xdh) extracellular region (Xdh)
peroxisome (Xdh) cytoplasm (Xdh)
Anatomy Link Frequency
erythrocytes 2
muscle 2
Xdh (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 7 99.98 Very High Very High Very High
Paracetamol 9 99.88 Very High Very High Very High
anesthesia 2 71.48 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 2 98.08 Very High Very High Very High
Disorder Of Lipid Metabolism 2 88.20 High High
Stress 4 87.36 High High
Hypertension 5 75.00 Quite High
Death 1 54.84 Quite High
Injury 2 50.72 Quite High
Necrosis 1 25.00 Low Low
Cardiovascular Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetaminophen also caused a long-lasting 50% reduction of the hepatic ATP content, an irreversible loss of hepatic xanthine dehydrogenase activity and a transient increase of the xanthine oxidase activity.
Positive_regulation (caused) of Positive_regulation (increase) of xanthine oxidase associated with paracetamol
1) Confidence 0.42 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2262912 Disease Relevance 0.25 Pain Relevance 0.49
These results suggest that dexamethasone induces an elevated level of XO activity in the cremaster muscle.
Positive_regulation (induces) of Positive_regulation (elevated) of XO in muscle associated with dexamethasone
2) Confidence 0.16 Published 2003 Journal Microvasc. Res. Section Abstract Doc Link 12826072 Disease Relevance 0.36 Pain Relevance 0.36
In conclusion, our results suggest that cholesterol feeding causes an increase in XO activity and a decrease in NOS activity in the erythrocytes from rats.
Positive_regulation (causes) of Positive_regulation (increase) of XO in erythrocytes
3) Confidence 0.02 Published 2008 Journal Nutr Res Section Abstract Doc Link 19083410 Disease Relevance 0.26 Pain Relevance 0.07

General Comments

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