INT222241

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.09
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) plasma membrane (Ccr2) cytoplasm (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
neurons 4
spinal 1
nerve 1
Ccr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 424 100.00 Very High Very High Very High
Neuropathic pain 72 100.00 Very High Very High Very High
Lasting pain 28 99.58 Very High Very High Very High
Demyelination 145 99.28 Very High Very High Very High
Dopamine 64 98.44 Very High Very High Very High
Pain 57 97.36 Very High Very High Very High
spinal stenosis 9 96.44 Very High Very High Very High
nociceptor 28 95.80 Very High Very High Very High
Stimulus evoked pain 12 91.28 High High
Inflammatory response 19 91.08 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 83 100.00 Very High Very High Very High
Pain 88 99.58 Very High Very High Very High
Demyelinating Disease 150 99.28 Very High Very High Very High
Spinal Stenosis 9 96.44 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 45 94.32 High High
Hypersensitivity 20 90.88 High High
INFLAMMATION 99 90.72 High High
Neurodegenerative Disease 10 89.68 High High
Nervous System Injury 100 80.88 Quite High
Rheumatoid Arthritis 55 78.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tissue sections were analyzed for the presence of IB4-binding neurons and either MCP-1, IP-10 or CCR2.
CCR2 Binding (binding) of in neurons
1) Confidence 0.42 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0 Pain Relevance 0
Tissue sections were analyzed for the presence of TRPV1 or IB4-binding neurons and either CXCR4 or CCR2.
CCR2 Spec (analyzed) Binding (binding) of in neurons
2) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.17 Pain Relevance 0.08
Interestingly, mice deficient in the chemokine receptor, CCR2, exhibit an impaired neuropathic pain response following partial nerve ligation [11].
CCR2 Spec (partial) Binding (ligation) of in nerve associated with chemokine and neuropathic pain
3) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.97 Pain Relevance 1.08
Several studies on the mechanisms underlying chronic pain have focused on the CCR2 and CXCR4 receptors, and their respective ligands, MCP1 and SDF1.
CCR2 Binding (receptors) of associated with lasting pain
4) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.85 Pain Relevance 0.46
The upregulation of MCP-1 and the CCR2 chemokine receptor observed in association with focal nerve demyelination is similar to the pattern we previously observed using a spinal stenosis model of neuropathic pain [8].
CCR2 chemokine receptor Binding (association) of in spinal associated with chemokine, demyelination, neuropathic pain and spinal stenosis
5) Confidence 0.32 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.78 Pain Relevance 1.04
MCP-1 is expressed and released by DA neurons when an activating stimulus continues to be present [39] and through interaction with its microglial receptor, chemokine receptor 2 (CCR2) [59,60], is able to direct the chemotaxis of microglia towards neurons to promote cell-cell contact [39].
CCR2 Binding (interaction) of in neurons associated with chemokine and dopamine
6) Confidence 0.18 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2292163 Disease Relevance 0.65 Pain Relevance 0.52
MCP-1 is expressed and released by DA neurons when an activating stimulus continues to be present [39] and through interaction with its microglial receptor, chemokine receptor 2 (CCR2) [59,60], is able to direct the chemotaxis of microglia towards neurons to promote cell-cell contact [39].
chemokine receptor 2 Binding (interaction) of in neurons associated with chemokine and dopamine
7) Confidence 0.18 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2292163 Disease Relevance 0.65 Pain Relevance 0.52

General Comments

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