INT222266

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.76
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOD2) plasma membrane (NOD2) enzyme binding (NOD2)
cytoplasm (NOD2)
Anatomy Link Frequency
monocytes 1
T cells 1
NOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 40 99.32 Very High Very High Very High
agonist 6 92.72 High High
Inflammation 60 81.28 Quite High
Crohn's disease 32 65.32 Quite High
Inflammatory stimuli 4 18.68 Low Low
tolerance 4 13.04 Low Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 64 81.28 Quite High
Crohn's Disease 24 79.36 Quite High
Disease 34 65.32 Quite High
Inflammatory Bowel Disease 12 64.72 Quite High
Apoptosis 16 54.28 Quite High
Repression 16 33.20 Quite Low
Cancer 14 8.56 Low Low
Infection 10 5.00 Very Low Very Low Very Low
Contagious Ecthyma 8 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A comparison of the 5'UTRs of the CARD15 mRNA species and those of the other members of the NOD family, APAF-1 and CARD4 (NOD1) indicated striking differences.
Transcription (species) of CARD15
1) Confidence 0.68 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.17 Pain Relevance 0.06
To analyze whether the ratio of the different UTR mRNA isoforms of NOD2 is regulated by cytokine stimulation, primary human monocytes were purified and stimulated for 12 h with TNF-?
Transcription (isoforms) of NOD2 in monocytes associated with cytokine
2) Confidence 0.68 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0 Pain Relevance 0.05
Furthermore, CARD15 mRNA isoforms in the databases differ in their 5' part and in the number of exons (AF178930[5]; AJ303140 [6]).
Transcription (isoforms) of CARD15
3) Confidence 0.68 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.19 Pain Relevance 0.06
Since the expression of Nod1 and Nod2 mRNA in HCE-T cells was similar and comparable to that of the primary corneal epithelial cells, we sought to investigate if HCE-T cells are able to recognize and respond a specific agonist.
Transcription (expression) of Nod2 in T cells associated with agonist
4) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.05
Albeit reciprocal mechanisms involved (increased vs. decreased exon skipping), these complex changes in splice patterns of NOD2 transcripts after TNF-?
Transcription (transcripts) of NOD2
5) Confidence 0.53 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.35 Pain Relevance 0.13
The transcription of Nod1, Nod2, NLRX1, Nalp1, and Cardinal was similar in the two cell types.
Transcription (transcription) of Nod2
6) Confidence 0.50 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2526096 Disease Relevance 0.05 Pain Relevance 0.08

General Comments

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