INT222271

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.32
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOD1) signal transduction (NOD1) plasma membrane (NOD1)
intracellular (NOD1) cytoplasm (NOD1)
Anatomy Link Frequency
T cells 2
corneal epithelial cells 1
NOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 59 93.08 High High
agonist 12 92.36 High High
Inflammation 43 57.40 Quite High
Inflammatory stimuli 1 12.12 Low Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Crohn's disease 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 32 92.56 High High
Inflammatory Bowel Disease 3 58.16 Quite High
INFLAMMATION 58 53.12 Quite High
Infection 20 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low
Crohn's Disease 6 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Uveitis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To have an insight into the cell type specific expression of another subfamily of NLRs, we measured the relative mRNA transcription of Nod family members in HCE-T cells and PRK samples (Figure 3A).
Transcription (transcription) of Nod in T cells
1) Confidence 0.66 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
Since the expression of Nod1 and Nod2 mRNA in HCE-T cells was similar and comparable to that of the primary corneal epithelial cells, we sought to investigate if HCE-T cells are able to recognize and respond a specific agonist.
Transcription (expression) of Nod1 in T cells associated with agonist
2) Confidence 0.63 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.05
The transcription of Nod1, Nod2, NLRX1, Nalp1, and Cardinal was similar in the two cell types.
Transcription (transcription) of Nod1
3) Confidence 0.49 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2526096 Disease Relevance 0.05 Pain Relevance 0.08
Constitutive and UV-B modulated transcription of Nod-like receptors and their functional partners in human corneal epithelial cells

Purpose

Transcription (transcription) of Nod in corneal epithelial cells
4) Confidence 0.49 Published 2008 Journal Molecular Vision Section Title Doc Link PMC2526096 Disease Relevance 0.09 Pain Relevance 0.03
A comparison of the 5'UTRs of the CARD15 mRNA species and those of the other members of the NOD family, APAF-1 and CARD4 (NOD1) indicated striking differences.
Transcription (species) of NOD1
5) Confidence 0.45 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.17 Pain Relevance 0.06

General Comments

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