INT222271

Context Info Confidence 0.66 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 5 Disease Relevance 0.32 Pain Relevance 0.21

cytosol (NOD1) signal transduction (NOD1) plasma membrane (NOD1) intracellular (NOD1) cytoplasm (NOD1)

Anatomy Link Frequency T cells 2 corneal epithelial cells 1 NOD1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 59 93.08 agonist 12 92.36 Inflammation 43 57.40 Inflammatory stimuli 1 12.12 Inflammatory response 12 5.00 Crohn's disease 8 5.00 Pain 4 5.00 Inflammatory mediators 4 5.00 antagonist 4 5.00 abdominal pain 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 32 92.56 Inflammatory Bowel Disease 3 58.16 INFLAMMATION 58 53.12 Infection 20 5.00 Injury 12 5.00 Disease 12 5.00 Cancer 7 5.00 Crohn's Disease 6 5.00 Hyperplasia 4 5.00 Uveitis 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To have an insight into the cell type specific expression of another subfamily of NLRs, we measured the relative mRNA transcription of Nod family members in HCE-T cells and PRK samples (Figure 3A).

Transcription (transcription) of Nod in T cells

1) Confidence 0.66 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0

Since the expression of Nod1 and Nod2 mRNA in HCE-T cells was similar and comparable to that of the primary corneal epithelial cells, we sought to investigate if HCE-T cells are able to recognize and respond a specific agonist.

Transcription (expression) of Nod1 in T cells associated with agonist

2) Confidence 0.63 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.05

The transcription of Nod1, Nod2, NLRX1, Nalp1, and Cardinal was similar in the two cell types.

Transcription (transcription) of Nod1

3) Confidence 0.49 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2526096 Disease Relevance 0.05 Pain Relevance 0.08

Constitutive and UV-B modulated transcription of Nod-like receptors and their functional partners in human corneal epithelial cells Purpose

Transcription (transcription) of Nod in corneal epithelial cells

4) Confidence 0.49 Published 2008 Journal Molecular Vision Section Title Doc Link PMC2526096 Disease Relevance 0.09 Pain Relevance 0.03

A comparison of the 5'UTRs of the CARD15 mRNA species and those of the other members of the NOD family, APAF-1 and CARD4 (NOD1) indicated striking differences.

Transcription (species) of NOD1

5) Confidence 0.45 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.17 Pain Relevance 0.06

General Comments

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