INT222289

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.24
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
astrocytes 2
Il18 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 67 100.00 Very High Very High Very High
Neuropathic pain 8 98.80 Very High Very High Very High
Inflammation 149 97.48 Very High Very High Very High
Hyperalgesia 154 86.40 High High
allodynia 16 81.84 Quite High
Angina 3 79.88 Quite High
hyperexcitability 2 69.04 Quite High
Lasting pain 18 68.40 Quite High
Glutamate 17 65.96 Quite High
Inflammatory marker 23 43.88 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 24 98.80 Very High Very High Very High
Pneumonia 7 97.48 Very High Very High Very High
Endotoxemia 5 96.24 Very High Very High Very High
INFLAMMATION 188 96.04 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 2 94.36 High High
Hyperalgesia 154 86.40 High High
Nervous System Injury 10 83.52 Quite High
Angina 3 79.88 Quite High
Sepsis 38 67.60 Quite High
Pain 42 67.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies suggest that IL-18, a member of the IL-1 cytokine family, is released from microglia and acts on the IL-18 receptor on astrocytes [79].
Localization (released) of IL-18 in astrocytes associated with cytokine
1) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.08 Pain Relevance 0.99
Recent studies suggest that IL-18, a member of the IL-1 cytokine family, is released from microglia and acts on the IL-18 receptor on astrocytes [79].
Localization (released) of IL-18 in astrocytes associated with cytokine
2) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.09 Pain Relevance 0.99
, IL-6, sCD40L, IL-8, MMP-9, TIMP-1, IL-18, and adiponectin.
Localization (sCD40L) of IL-18
3) Confidence 0.13 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.26 Pain Relevance 0.14
The secretion of mature and bioactive IL-1ß and IL-18 depends on the activity of the enzyme caspase-1, a limiting step in the biosynthesis of these pro-inflammatory cytokines.
Localization (secretion) of IL-18 associated with inflammation and cytokine
4) Confidence 0.11 Published 2008 Journal Intensive Care Med Section Body Doc Link PMC2228383 Disease Relevance 0.82 Pain Relevance 0.46

General Comments

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