INT222291

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 0.94
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Trim63) intracellular (Trim63) ligase activity (Trim63)
cytoplasm (Trim63)
Anatomy Link Frequency
skeletal muscle 2
finger 2
myocardium 1
Trim63 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 46 70.60 Quite High
Spinal cord 14 31.16 Quite Low
cva 38 5.00 Very Low Very Low Very Low
Inflammation 30 5.00 Very Low Very Low Very Low
ischemia 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
nalbuphine 6 5.00 Very Low Very Low Very Low
analgesia 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Clonidine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Atrophy 8 89.28 High High
Sepsis 94 87.32 High High
Lung Injury 34 80.24 Quite High
Myocardial Infarction 14 62.56 Quite High
Pressure Volume 2 Under Development 22 58.72 Quite High
Heart Rate Under Development 30 58.08 Quite High
Brain Injury 42 50.00 Quite Low
Renal Failure 2 50.00 Quite Low
Infection 6 48.76 Quite Low
Critical Illness 54 36.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the same time point, a significant increase in MAFbx/atrogin-1 and MuRF1 mRNA (3.7±0.7- and 19.5±1.9-fold increase vs. controls, respectively; P<0.05), in addition to protein levels of ?
Positive_regulation (increase) of MuRF1 mRNA
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
and IL-6 mRNA levels precedes increases in both MAFbx/atrogin-1 and MuRF1.
Positive_regulation (increases) of MuRF1
2) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.22 Pain Relevance 0.04
We have recently shown the induction of lipopolysaccharide (LPS)-induced endotoxaemia in rodents to result in the reduction of total AKT protein levels, decreased cytosolic Foxo1 and Foxo3 phosphorylation, and increased levels of MAFbx/atrogin-1 protein and MuRF1 mRNA in fast-twitch skeletal muscle [3], where MAFbx/atrogin-1 and MuRF1 are considered important in the development of skeletal muscle proteolysis during catabolic events [4]–[6].
Positive_regulation (increased) of MuRF1 mRNA in skeletal muscle
3) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.16 Pain Relevance 0
Consistent with our previously reported findings [3], we observed 24 h LPS administration to result in reduced fast-twitch skeletal muscle protein content, elevated mRNA levels of MAFbx/atrogin-1 and MuRF1, and an increase in protein levels for multiple subunits of the 20S proteasome; observations that are in accordance with the reported rise in UP-mediated protein degradation during endotoxaemia in fast-twitch muscle [32].
Positive_regulation (elevated) of MuRF1 in skeletal muscle
4) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
It is feasible that this is in part a consequence of the failure of the myocardium to elicit events typically associated with UP-mediated protein degradation, most notably MAFbx/atrogin-1 and MuRF1 mRNA elevation.
Positive_regulation (elevation) of MuRF1 mRNA in myocardium
5) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.05 Pain Relevance 0
Thus, elevated levels of MAFbx/atrogin-1 mRNA at 6 h plateaued, whereas in contrast, MuRF1 mRNA levels were substantially elevated from the 6 h to the 24 h time-point.
Positive_regulation (elevated) of MuRF1 mRNA
6) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.17 Pain Relevance 0
The levels of diaphragm muscle RING-finger protein-1 (MURF-1) mRNA and the protease calpain were increased after rocuronium, while unchanged in the cisatracurium-treated groups.
Positive_regulation (increased) of diaphragm muscle RING-finger protein-1 in finger
7) Confidence 0.08 Published 2008 Journal Intensive Care Med Section Body Doc Link PMC2228383 Disease Relevance 0.17 Pain Relevance 0
The levels of diaphragm muscle RING-finger protein-1 (MURF-1) mRNA and the protease calpain were increased after rocuronium, while unchanged in the cisatracurium-treated groups.
Positive_regulation (increased) of MURF-1 in finger
8) Confidence 0.08 Published 2008 Journal Intensive Care Med Section Body Doc Link PMC2228383 Disease Relevance 0.17 Pain Relevance 0

General Comments

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