INT222294

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Trim63) intracellular (Trim63) ligase activity (Trim63)
cytoplasm (Trim63)
Anatomy Link Frequency
skeletal muscle 4
muscle 2
finger 2
Trim63 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 23 5.00 Very Low Very Low Very Low
cva 19 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
Spinal cord 7 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
nalbuphine 3 5.00 Very Low Very Low Very Low
analgesia 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Clonidine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Atrophy 4 89.28 High High
Lung Injury 17 80.24 Quite High
Brain Injury 21 50.00 Quite Low
Renal Failure 1 50.00 Quite Low
Infection 3 49.16 Quite Low
Sepsis 47 39.80 Quite Low
Critical Illness 27 37.20 Quite Low
Pulmonary Edema 3 27.04 Quite Low
Injury 23 5.00 Very Low Very Low Very Low
INFLAMMATION 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with our previously reported findings [3], we observed 24 h LPS administration to result in reduced fast-twitch skeletal muscle protein content, elevated mRNA levels of MAFbx/atrogin-1 and MuRF1, and an increase in protein levels for multiple subunits of the 20S proteasome; observations that are in accordance with the reported rise in UP-mediated protein degradation during endotoxaemia in fast-twitch muscle [32].
Positive_regulation (increase) of Transcription (levels) of MuRF1 in skeletal muscle
1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Consistent with our previously reported findings [3], we observed 24 h LPS administration to result in reduced fast-twitch skeletal muscle protein content, elevated mRNA levels of MAFbx/atrogin-1 and MuRF1, and an increase in protein levels for multiple subunits of the 20S proteasome; observations that are in accordance with the reported rise in UP-mediated protein degradation during endotoxaemia in fast-twitch muscle [32].
Positive_regulation (elevated) of Transcription (levels) of MuRF1 in skeletal muscle
2) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
However, when present in the nucleus, Foxo1, Foxo3 and Foxo4 can induce the transcription of the two muscle-specific ubiquitin ligases, MAFbx/atrogin-1 and MuRF1, which are thought responsible for the specific targeting of proteins for subsequent degradation by the proteasome [7], [8].
Positive_regulation (induce) of Transcription (transcription) of MuRF1 in muscle
3) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
The levels of diaphragm muscle RING-finger protein-1 (MURF-1) mRNA and the protease calpain were increased after rocuronium, while unchanged in the cisatracurium-treated groups.
Positive_regulation (increased) of Transcription (levels) of MURF-1 in finger
4) Confidence 0.06 Published 2008 Journal Intensive Care Med Section Body Doc Link PMC2228383 Disease Relevance 0.17 Pain Relevance 0

General Comments

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