INT222299

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYP19A1) small molecule metabolic process (CYP19A1) endoplasmic reticulum (CYP19A1)
cytoplasm (CYP19A1)
CYP19A1 (Homo sapiens)
AIS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 5 65.96 Quite High
Inflammation 4 65.56 Quite High
agonist 5 62.04 Quite High
antagonist 1 61.12 Quite High
cva 11 56.88 Quite High
Pain 4 5.00 Very Low Very Low Very Low
sSRI 3 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
Gabapentin 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vomiting 2 89.52 High High
Ataxia 1 88.68 High High
Dizziness 1 88.36 High High
Fatigue 3 87.92 High High
Exanthema 1 87.56 High High
Reprotox - General 2 5 83.68 Quite High
Reprotox - General 1 48 82.32 Quite High
Arthralgia 22 80.32 Quite High
Breast Disease 3 72.84 Quite High
Advanced Or Metastatic Breast Cancer 9 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AIs are categorized in two types, non-steroidal and steroidal, and differ in their modes of interaction with the aromatase-enzymatic complex and its inactivation.
aromatase Binding (interaction) of AIs
1) Confidence 0.25 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.32 Pain Relevance 0.12
Non-steroidal AIs reversibly bind to the aromatase enzyme and include anastrozole and letrozole.
aromatase enzyme Binding (bind) of AIs
2) Confidence 0.11 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 1.33 Pain Relevance 0.19

General Comments

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