INT222308

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1R) plasma membrane (IGF1R)
IGF1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 20 5.00 Very Low Very Low Very Low
cva 10 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
cINOD 7 5.00 Very Low Very Low Very Low
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
sSRI 6 5.00 Very Low Very Low Very Low
Dismenorea 4 5.00 Very Low Very Low Very Low
Gabapentin 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 4 98.98 Very High Very High Very High
Cancer 124 94.04 High High
Metastasis 18 87.00 High High
Polyps 3 80.84 Quite High
Aberrant Crypt Foci 2 80.40 Quite High
Colon Cancer 35 77.20 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 76.16 Quite High
Breast Cancer 9 75.80 Quite High
Arthralgia 20 65.60 Quite High
Breast Disease 6 50.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These include: (i) development of hypersensitivity of the ER to very low levels of estrogen; (ii) up-regulation of growth factor receptors and/or associated signalling pathways (HER-2, EGFR and insulin growth factor receptor (IGFR)) (92,93).
Regulation (regulation) of IGFR associated with hypersensitivity
1) Confidence 0.12 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 0.64 Pain Relevance 0
These include: (i) development of hypersensitivity of the ER to very low levels of estrogen; (ii) up-regulation of growth factor receptors and/or associated signalling pathways (HER-2, EGFR and insulin growth factor receptor (IGFR)) (92,93).
Regulation (regulation) of insulin growth factor receptor associated with hypersensitivity
2) Confidence 0.12 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 0.63 Pain Relevance 0
Cholesterol by modulating caveolae formation regulates several signaling molecules like AKT, IGFR, EGFR and Rho which are involved in cell growth and survival.
Regulation (regulates) of IGFR
3) Confidence 0.12 Published 2008 Journal Gene Regulation and Systems Biology Section Abstract Doc Link PMC2745153 Disease Relevance 0.91 Pain Relevance 0

General Comments

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