INT222335

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.66
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
cytoplasm (Ngfr) signal transduction (Ngfr) extracellular region (Bdnf)
Anatomy Link Frequency
spines 2
sympathetic 2
Bdnf (Rattus norvegicus)
Ngfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 2 98.68 Very High Very High Very High
Nerve growth factor 4 91.48 High High
Neurotransmitter 10 89.52 High High
Glutamate 2 88.00 High High
gABA 2 87.12 High High
Hippocampus 20 85.64 High High
Dopamine 6 83.28 Quite High
cytokine 18 76.52 Quite High
intrathecal 2 76.48 Quite High
Inflammation 22 76.12 Quite High
Disease Link Frequency Relevance Heat
Death 32 100.00 Very High Very High Very High
Apoptosis 50 96.52 Very High Very High Very High
Neurodegenerative Disease 8 83.52 Quite High
Spinal Cord Injury 58 77.64 Quite High
INFLAMMATION 34 76.12 Quite High
Stress 30 72.56 Quite High
Depression 236 71.68 Quite High
Pain 26 55.68 Quite High
Neuropathic Pain 2 55.48 Quite High
Hypersensitivity 2 44.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, when sympathetic neurons, expressing p75 and TrkA surface receptors, were presented with the neurotrophic molecule BDNF, subsequent binding of BDNF to the p75NTR without binding to TrkB ultimately led to the death of the neurons via p75NTR induced apoptosis [76,77].
BDNF Binding (binding) of p75NTR in sympathetic associated with apoptosis and death
1) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.33 Pain Relevance 0.11
For instance, when sympathetic neurons, expressing p75 and TrkA surface receptors, were presented with the neurotrophic molecule BDNF, subsequent binding of BDNF to the p75NTR without binding to TrkB ultimately led to the death of the neurons via p75NTR induced apoptosis [76,77].
BDNF Binding (binding) of p75NTR in sympathetic associated with apoptosis and death
2) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.32 Pain Relevance 0.11
However, the precursor form of BDNF (pro-BDNF) can also precipitate reduction in dendritic spines and cell death when it binds with the p75 receptor.
BDNF Binding (binds) of p75 receptor in spines associated with death
3) Confidence 0.01 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228409 Disease Relevance 1.00 Pain Relevance 0.63
However, the precursor form of BDNF (pro-BDNF) can also precipitate reduction in dendritic spines and cell death when it binds with the p75 receptor.
pro-BDNF Binding (binds) of p75 receptor in spines associated with death
4) Confidence 0.01 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228409 Disease Relevance 1.00 Pain Relevance 0.63

General Comments

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