INT22235

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Context Info
Confidence 0.76
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.40
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Eln) extracellular region (Eln) proteinaceous extracellular matrix (Eln)
extracellular matrix organization (Eln)
Anatomy Link Frequency
fat 2
ligaments 1
smooth muscle 1
fibroblasts 1
face 1
Eln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 12 98.66 Very High Very High Very High
Angina 7 91.48 High High
anesthesia 5 87.92 High High
fibrosis 6 87.32 High High
dexamethasone 48 84.92 Quite High
Snapping jaw 3 75.00 Quite High
corticosteroid 8 66.24 Quite High
Nerve growth factor 1 7.88 Low Low
cva 12 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 2 99.32 Very High Very High Very High
Williams-beuren Syndrome 30 98.92 Very High Very High Very High
INFLAMMATION 11 98.66 Very High Very High Very High
Hypertension 21 98.48 Very High Very High Very High
Cv General 3 Under Development 16 91.48 High High
Necrosis 2 89.32 High High
Fibrosis 6 87.32 High High
Hypertrophy 4 86.92 High High
Cleidocranial Dysplasia 3 86.72 High High
Atherosclerotic Plaque 3 82.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Radioimmunoassay also indicated that elastin was present in these tissues.
Gene_expression (present) of elastin
1) Confidence 0.76 Published 1990 Journal Arch. Oral Biol. Section Abstract Doc Link 2264798 Disease Relevance 0.07 Pain Relevance 0.07
Histologic and morphologic parameters of the aortic media, including cross-sectional area and thickness, size, and density of smooth muscle nuclei and of elastin and collagen fibers, were measured using an automated image analysis system.
Gene_expression (thickness) of elastin in smooth muscle
2) Confidence 0.57 Published 1993 Journal Am. J. Cardiol. Section Abstract Doc Link 8328370 Disease Relevance 0.29 Pain Relevance 0.09
Each of the specimens was examined for the presence of inflammation, amount of vascularity, arterial wall thickness, presence of fat, appearance of collagen, and amount of elastin present.
Gene_expression (appearance) of elastin in fat associated with inflammation
3) Confidence 0.39 Published 1984 Journal Oral Surg. Oral Med. Oral Pathol. Section Abstract Doc Link 6593661 Disease Relevance 0.26 Pain Relevance 0.17
Each of the specimens was examined for the presence of inflammation, amount of vascularity, arterial wall thickness, presence of fat, appearance of collagen, and amount of elastin present.
Gene_expression (present) of elastin in fat associated with inflammation
4) Confidence 0.39 Published 1984 Journal Oral Surg. Oral Med. Oral Pathol. Section Abstract Doc Link 6593661 Disease Relevance 0.26 Pain Relevance 0.17
This pattern corresponds to myo-elastic intimal hyperplasia ("intimal thickening") where the production of intimal elastin constitutes an essential phenomenon.
Gene_expression (production) of elastin in thickening associated with hyperplasia
5) Confidence 0.16 Published 1999 Journal Pol J Pathol Section Abstract Doc Link 10481532 Disease Relevance 0.94 Pain Relevance 0.47
There is an increase in the dermal volume, as increased collagen production, glycosaminoglycan, and elastin fragmentation and reorganization is seen.
Gene_expression (production) of elastin
6) Confidence 0.07 Published 2010 Journal Journal of Cutaneous and Aesthetic Surgery Section Body Doc Link PMC2956965 Disease Relevance 0.63 Pain Relevance 0
However, impaired vascular elastin production without clinical signs of Williams syndrome may affect some (pediatric) patients.
Gene_expression (production) of elastin associated with williams-beuren syndrome
7) Confidence 0.07 Published 2007 Journal Cardiovasc Intervent Radiol Section Body Doc Link PMC2700243 Disease Relevance 0.82 Pain Relevance 0.04
These lipid-rich fibroblasts play a key role in producing elastin at the sites of new secondary septa [38,39].
Gene_expression (producing) of elastin in fibroblasts
8) Confidence 0.07 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.27 Pain Relevance 0.13
Deletion of the long arm of chromosome 7 (7q11.23), which encodes for the elastin gene, results in decreased elastin production, affecting the heart, face, and bones.
Gene_expression (production) of elastin in heart
9) Confidence 0.06 Published 2007 Journal Cardiovasc Intervent Radiol Section Body Doc Link PMC2700243 Disease Relevance 0.89 Pain Relevance 0.04
Similarly, transfer of IGF-1 cDNA by using an adenovirus vector led to the synthesis and deposition of increased amounts of types I and III collagen, elastin, tenascin, and vimentin in the same model[111]; thus confirming the potential of using vector-laden hydrogels for the in situ delivery of genes to damaged ligaments for potential biological repair of the ACL.


Gene_expression (synthesis) of elastin in ligaments
10) Confidence 0.03 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2879239 Disease Relevance 0.07 Pain Relevance 0
Deletion of the long arm of chromosome 7 (7q11.23), which encodes for the elastin gene, results in decreased elastin production, affecting the heart, face, and bones.
Gene_expression (production) of elastin in face
11) Confidence 0.02 Published 2007 Journal Cardiovasc Intervent Radiol Section Body Doc Link PMC2700243 Disease Relevance 0.89 Pain Relevance 0.04

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