INT22237

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Context Info
Confidence 0.75
First Reported 1984
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 5.50
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (NTS) extracellular region (NTS)
Anatomy Link Frequency
cerebral cortex 2
colon 1
nerves 1
nucleus 1
NMU 1
NTS (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 23 100.00 Very High Very High Very High
Dopamine 7 100.00 Very High Very High Very High
cerebral cortex 4 97.84 Very High Very High Very High
Serotonin 12 97.80 Very High Very High Very High
gABA 4 96.88 Very High Very High Very High
bradykinin 5 95.48 Very High Very High Very High
Enkephalin 6 92.96 High High
Neuropeptide 32 92.28 High High
alcohol 19 83.04 Quite High
Inflammation 10 82.24 Quite High
Disease Link Frequency Relevance Heat
Carcinoid 48 100.00 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 186 99.92 Very High Very High Very High
Dysphagia 93 97.72 Very High Very High Very High
Cancer 14 95.96 Very High Very High Very High
Urological Neuroanatomy 2 92.48 High High
Heart Rate Under Development 1 90.56 High High
Colon Cancer 1 90.20 High High
Respiratory Sounds 1 88.40 High High
Diarrhoea 1 87.60 High High
Increased Venous Pressure Under Development 2 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of neurotensin as a physiologic regulator of exocrine pancreatic secretion is known, but the hormone has only recently been recognized as important mitogen in vitro for human cancer cells.
Localization (secretion) of neurotensin associated with cancer
1) Confidence 0.75 Published 1996 Journal Tumori Section Abstract Doc Link 9061071 Disease Relevance 0.77 Pain Relevance 0.18
We have localized neurotensin (NT) with immunocytochemical methods in the normal human cerebral cortex.
Localization (localized) of NT in cerebral cortex associated with cerebral cortex
2) Confidence 0.68 Published 1990 Journal Brain Res. Section Abstract Doc Link 2265353 Disease Relevance 0.09 Pain Relevance 0.15
We have localized neurotensin (NT) with immunocytochemical methods in the normal human cerebral cortex.
Localization (localized) of neurotensin in cerebral cortex associated with cerebral cortex
3) Confidence 0.68 Published 1990 Journal Brain Res. Section Abstract Doc Link 2265353 Disease Relevance 0.09 Pain Relevance 0.15
There is also evidence for some cardiovascular nerves with gastrin releasing peptide and neurotensin immunoreactivity.
Localization (releasing) of neurotensin in nerves
4) Confidence 0.43 Published 1984 Journal Clin Exp Hypertens A Section Abstract Doc Link 6199137 Disease Relevance 0 Pain Relevance 0.53
Altogether, our results indicate that porcine endopeptidase 3.4.24.16 cleaves neurotensin at a unique site, leading to the formation of neurotensin(1-10) and that the production of neurotensin(1-8) is due to contaminating endopeptidase 3.4.24.15.
Localization (formation) of neurotensin
5) Confidence 0.40 Published 1996 Journal Brain Res. Section Abstract Doc Link 8869556 Disease Relevance 0 Pain Relevance 0.05
Characterization and autoradiographic localization of neurotensin binding sites in human sigmoid colon.
Localization (localization) of neurotensin in colon
6) Confidence 0.39 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 11356931 Disease Relevance 0.09 Pain Relevance 0
In both settings, PP levels were significantly increased after bethanechol, while release of neurotensin, motilin, gastrin and cholylglycine was unaffected.
Localization (release) of neurotensin
7) Confidence 0.35 Published 2005 Journal Neurogastroenterol. Motil. Section Body Doc Link 16185316 Disease Relevance 0 Pain Relevance 0
ACE hydrolyzed NT at Tyr11-Ile12 to release Ile12-Leu13.
Localization (release) of NT
8) Confidence 0.27 Published 1984 Journal Peptides Section Abstract Doc Link 6208535 Disease Relevance 0 Pain Relevance 0.62
Group A7 is also composed of receptors for peptide ligands: neuromedin, neurotensin, motilin, endothelin, bombesin and the releasing hormones for growth hormone and thyrotropin.
Localization (releasing) of neurotensin
9) Confidence 0.25 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.27
Other hormones and biochemical substances secreted from carcinoid tumors include corticotropin, histamine, dopamine, substance P, neurotensin, prostaglandins and kallikrein.
Localization (secreted) of neurotensin associated with carcinoid, dopamine and substance p
10) Confidence 0.15 Published 2010 Journal BMC Urol Section Body Doc Link PMC3016340 Disease Relevance 1.58 Pain Relevance 0.32
Neural activity in the nucleus tractus solitarius (NTS) is inhibited by ?
Localization (solitarius) of NTS in nucleus
11) Confidence 0.14 Published 2011 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2929516 Disease Relevance 0.48 Pain Relevance 0.20
Clinically significant discordance between NT and biopsy was defined as a two classification discordance: NASH as predicted by NT and no Nash as observed at biopsy; or the inverse, no Nash as predicted by NT and Nash as observed at biopsy.
Localization (predicted) of NT associated with nash(non-alcoholic steatohepatitis)
12) Confidence 0.08 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.18 Pain Relevance 0.11
Clinically significant discordance between NT and biopsy was defined as a two classification discordance: NASH as predicted by NT and no Nash as observed at biopsy; or the inverse, no Nash as predicted by NT and Nash as observed at biopsy.
Neg (no) Localization (predicted) of NT associated with nash(non-alcoholic steatohepatitis)
13) Confidence 0.08 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.22 Pain Relevance 0.11
Cluster 5 is composed of receptors for neurotensin (NT), neuromedin U (NMU), motilin, growth hormone secretagogue, thyrotropin-releasing hormone and some of PRX-amide peptides.
Localization (secretagogue) of neurotensin in NMU
14) Confidence 0.08 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0 Pain Relevance 0.07

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