INT22239

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Context Info
Confidence 0.57
First Reported 1983
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 52
Total Number 54
Disease Relevance 12.96
Pain Relevance 31.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC1) extracellular region (TAC1) plasma membrane (TAC1)
cell-cell signaling (TAC1)
Anatomy Link Frequency
spinal cord 2
large granular lymphocyte 2
synovial fluid 1
macrophages 1
brain 1
TAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 117 100.00 Very High Very High Very High
Neuropeptide 69 100.00 Very High Very High Very High
antagonist 68 100.00 Very High Very High Very High
lidocaine 68 100.00 Very High Very High Very High
Opioid 27 100.00 Very High Very High Very High
gABA 2 100.00 Very High Very High Very High
Cholecystokinin 1 100.00 Very High Very High Very High
corticosteroid 2 99.92 Very High Very High Very High
narcan 16 99.84 Very High Very High Very High
Enkephalin 22 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cough 10 100.00 Very High Very High Very High
Thyroid Disease 1 99.76 Very High Very High Very High
Cancer 19 99.74 Very High Very High Very High
Constipation 6 99.72 Very High Very High Very High
Sleep Disorders 11 99.70 Very High Very High Very High
Systemic Lupus Erythematosus 11 99.64 Very High Very High Very High
Bronchospasm 3 99.56 Very High Very High Very High
Disease 13 99.48 Very High Very High Very High
Osteoarthritis 2 99.28 Very High Very High Very High
Respiratory Disease 4 98.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study shows that, for 90% of the cases studied here (excluding one hypothyroidism case), the tachykinin A neuropeptide SP-LI level is decreased, the POMC peptide BE level is not altered, and the proenkephalin A neuropeptide ME level is increased in these PRL-secreting tumors.
Negative_regulation (decreased) of tachykinin associated with cancer, thyroid disease, neuropeptide, enkephalin and substance p
1) Confidence 0.57 Published 1995 Journal Peptides Section Abstract Doc Link 8532594 Disease Relevance 0.35 Pain Relevance 0.94
Conversely, treatment of SLE-FM patients with inhibitors of NMDA or neurokinin receptors may prevent or alleviate cognitive abnormalities and chronic pain, as well as FM.
Negative_regulation (inhibitors) of neurokinin associated with cognitive disorder, congenital anomalies, lasting pain, systemic lupus erythematosus and fibrositis
2) Confidence 0.57 Published 2006 Journal Curr Rheumatol Rep Section Abstract Doc Link 17092442 Disease Relevance 2.57 Pain Relevance 0.86
Lidocaine's inhibition of NK activity remained the same for cells which were further purified by plastic adherence, nylon wool filtration and percoll density centrifugation.
Negative_regulation (inhibition) of NK associated with lidocaine
3) Confidence 0.56 Published 1990 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 2266230 Disease Relevance 0 Pain Relevance 0.80
When the synaptic transmission in the spinal cord was blocked by tetrodotoxin, the depolarizing action of neurokinin alpha and neurokinin beta was markedly reduced but not completely abolished.
Negative_regulation (reduced) of neurokinin beta in spinal cord associated with tetrodotoxin and spinal cord
4) Confidence 0.50 Published 1984 Journal Neurosci. Res. Section Abstract Doc Link 6085649 Disease Relevance 0 Pain Relevance 0.40
Premature newborns from control group, in the dynamics of neonatal period, manifested reliable reduction (R<0,05) of neurokinin A from 17.52 to 2.08 ng/ml, substance P from 2.5 to 0.3 n/ml compare to seek newborns.
Negative_regulation (reduction) of neurokinin A associated with substance p
5) Confidence 0.42 Published 2009 Journal Georgian Med News Section Abstract Doc Link 19430045 Disease Relevance 0.49 Pain Relevance 0.97
The data suggested that psychological stress causes release of substance P in the limbic system of the brain, and that pharmacological blockade of substance P receptors is capable of inhibiting behavioural responses to such stress [97].


Negative_regulation (blockade) of substance P in brain associated with stress, limbic system and substance p
6) Confidence 0.42 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416451 Disease Relevance 1.30 Pain Relevance 0.97
The same effect was observed after blockade of neurokinin 1 receptors within the lateral parabrachial nucleus, indicating a possible involvement for substance P as a neurotransmitter.
Negative_regulation (blockade) of neurokinin 1 in lateral associated with neurotransmitter, substance p and parabrachial
7) Confidence 0.41 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15703395 Disease Relevance 0.24 Pain Relevance 0.53
In addition, this C-fiber dependency is likely related to neuropeptide substance P release and activity because blockade of tachykinin NK1 receptors (66.3+/-13.7% inhibition, n=6; P<0.001), and not NK2 receptors (n=4, NS), almost abolished the myogenic response.
Negative_regulation (blockade) of NK2 associated with c fibre, neuropeptide and substance p
8) Confidence 0.41 Published 2004 Journal Circ. Res. Section Abstract Doc Link 15499026 Disease Relevance 0 Pain Relevance 0.61
Blockade of tachykinergic NK2 receptors attenuated IL-1 beta induced inhibition of LH secretion.
Negative_regulation (Blockade) of NK2
9) Confidence 0.41 Published 1998 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 9785036 Disease Relevance 0.36 Pain Relevance 0.54
Thus, blockade of neurokinin 1 receptors reduces the sensitized responses to innocuous mechanical stimuli but not to noxious mechanical stimuli.
Negative_regulation (blockade) of neurokinin 1
10) Confidence 0.41 Published 1998 Journal Exp Brain Res Section Abstract Doc Link 9746141 Disease Relevance 0.06 Pain Relevance 0.67
Excitatory nerve fibres are present in the circular muscle in STC but they are deficient in tachykinins and enkephalin.
Negative_regulation (deficient) of tachykinin in nerve associated with constipation and enkephalin
11) Confidence 0.41 Published 1998 Journal Int J Colorectal Dis Section Abstract Doc Link 9870163 Disease Relevance 0.57 Pain Relevance 0.29
These data suggest that a hypometabolism of the POMC precursor may be operating in non-secreting tumors, and that a hypermetabolism of the proenkephalin A, POMC, and tachykinin precursors may be operating in two ACTH-secreting tumors.
Negative_regulation (hypermetabolism) of tachykinin associated with cancer
12) Confidence 0.41 Published 1993 Journal Biol. Mass Spectrom. Section Abstract Doc Link 8381675 Disease Relevance 0.68 Pain Relevance 0.77
Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils.
Negative_regulation (blockade) of NK2 associated with antidepressant and anxiety disorder
13) Confidence 0.38 Published 2006 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 16624395 Disease Relevance 0.35 Pain Relevance 0.34
Topical application of capsaicin is thought to deplete substance P from local sensory nerve terminals.
Negative_regulation (deplete) of substance P in sensory nerve associated with qutenza and substance p
14) Confidence 0.38 Published 1986 Journal Acta Derm. Venereol. Section Abstract Doc Link 2431572 Disease Relevance 0.25 Pain Relevance 0.64
The decrease in NK cell cytotoxicity was only moderate and not statistically significant in all other elderly and young subjects.
Negative_regulation (decrease) of NK in NK cell
15) Confidence 0.37 Published 2005 Journal Isr. Med. Assoc. J. Section Body Doc Link 15729955 Disease Relevance 0.05 Pain Relevance 0
This result supports that naloxone has the antagonizable inhibitory effect of substance-P.
Negative_regulation (effect) of substance-P associated with narcan
16) Confidence 0.37 Published 1984 Journal Tokai J. Exp. Clin. Med. Section Abstract Doc Link 6537670 Disease Relevance 0.49 Pain Relevance 1.30
We have previously found that NK cell activity is present in rat lung lavage and inhibited by lidocaine.
Negative_regulation (inhibited) of NK in lung associated with lidocaine
17) Confidence 0.36 Published 1990 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 2266230 Disease Relevance 0 Pain Relevance 0.53
During the assay, increasing concentrations of lidocaine inhibited NK activity.
Negative_regulation (inhibited) of NK associated with lidocaine
18) Confidence 0.36 Published 1990 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 2266230 Disease Relevance 0 Pain Relevance 0.81
The purpose of this report is to characterize further the inhibition by lidocaine on NK activity.
Negative_regulation (inhibition) of NK associated with lidocaine
19) Confidence 0.36 Published 1990 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 2266230 Disease Relevance 0 Pain Relevance 0.57
CS-003 is a potent antagonist of triple neurokinin receptors and may achieve the best therapeutic efficacy on respiratory diseases associated with neurokinins compared to selective neurokinin receptor antagonists.
Negative_regulation (antagonists) of neurokinin in respiratory associated with antagonist and respiratory disease
20) Confidence 0.35 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18353309 Disease Relevance 0.19 Pain Relevance 0.39

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