INT222412

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd14, Tlr4) signal transduction (Tlr4) extracellular space (Cd14)
intracellular (Tlr4) cytoplasm (Tlr4) response to stress (Cd14)
Anatomy Link Frequency
pituitary 2
Cd14 (Rattus norvegicus)
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 27 88.20 High High
cytokine 22 85.56 High High
antagonist 39 57.12 Quite High
Nerve growth factor 28 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Dopamine 13 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 22 93.52 High High
INFLAMMATION 28 88.20 High High
Stress 48 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Hyperplasia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An antibody blocking LPS action at CD14 abolished both LPS-induced IL-6, as well as ACTH secretion in aggregate cultures, and a neutralising anti-IL-6 antibody also blocked LPS-induced ACTH secretion in pituitary cell aggregates (700).
CD14 Negative_regulation (blocking) of LPS Binding (action) of in pituitary
1) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.26 Pain Relevance 0.27

General Comments

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