INT222420

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tlr4) carbohydrate metabolic process (Hpse) cytoplasm (Tlr4)
signal transduction (Tlr4) extracellular region (Hpse) hydrolase activity, acting on glycosyl bonds (Hpse)
Anatomy Link Frequency
pituitary 2
Tlr4 (Mus musculus)
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 27 94.28 High High
cytokine 22 87.36 High High
antagonist 39 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Dopamine 13 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 22 95.12 Very High Very High Very High
Stress 48 94.56 High High
INFLAMMATION 28 94.28 High High
Cytomegalovirus Infection 1 25.84 Quite Low
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, although null mutation of either CRH or LIF blunts the LPS-induced HPA activation, mice in which both CRH and LIF genes were deleted show a normal HPA axis response to LPS (713), showing that plasticity in the pituitary can compensate for the lacking factors.
LPS Positive_regulation (induced) of Positive_regulation (activation) of HPA in pituitary
1) Confidence 0.00 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.67 Pain Relevance 0.15

General Comments

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