INT222427

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, Pomc) extracellular region (Il6, Pomc) signal transduction (Pomc)
generation of precursor metabolites and energy (Pomc) aging (Il6) cell-cell signaling (Pomc)
Anatomy Link Frequency
pituitary 2
Il6 (Rattus norvegicus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 22 74.16 Quite High
Inflammation 27 70.40 Quite High
antagonist 39 39.32 Quite Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Dopamine 13 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 22 75.72 Quite High
INFLAMMATION 28 70.40 Quite High
Cytomegalovirus Infection 1 36.56 Quite Low
Stress 48 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6 receptors are expressed in corticotrophs and IL-6 can stimulate ACTH secretion directly at the pituitary level (701).
IL-6 Positive_regulation (stimulate) of Localization (secretion) of ACTH in pituitary
1) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.27 Pain Relevance 0.26

General Comments

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