INT222440

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.35
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tlr4, Pomc) signal transduction (Tlr4, Pomc) intracellular (Tlr4)
cell-cell signaling (Pomc) extracellular space (Pomc) generation of precursor metabolites and energy (Pomc)
Anatomy Link Frequency
pituitary 4
Tlr4 (Mus musculus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 81 81.76 Quite High
cytokine 66 79.12 Quite High
antagonist 117 50.68 Quite High
Nerve growth factor 84 5.00 Very Low Very Low Very Low
agonist 66 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 51 5.00 Very Low Very Low Very Low
substance P 48 5.00 Very Low Very Low Very Low
gABA 45 5.00 Very Low Very Low Very Low
Dopamine 39 5.00 Very Low Very Low Very Low
Glutamate 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 66 87.08 High High
INFLAMMATION 84 81.76 Quite High
Stress 144 58.12 Quite High
Cytomegalovirus Infection 3 13.28 Low Low
Cancer 66 9.60 Low Low
Pituitary Cancer 33 5.00 Very Low Very Low Very Low
Starvation 30 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 24 5.00 Very Low Very Low Very Low
Natriuresis 21 5.00 Very Low Very Low Very Low
Adhesions 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although LPS stimulates IL-6 secretion in monolayer as well as in mouse pituitary cell aggregates, LPS can stimulate ACTH secretion only in aggregates (700).
LPS Positive_regulation (stimulate) of Localization (secretion) of ACTH in pituitary
1) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.05 Pain Relevance 0
The stimulation of ACTH secretion by LPS is also dependent on a compact cellular organisation.
LPS Positive_regulation (stimulation) of Localization (secretion) of ACTH
2) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.06 Pain Relevance 0
An antibody blocking LPS action at CD14 abolished both LPS-induced IL-6, as well as ACTH secretion in aggregate cultures, and a neutralising anti-IL-6 antibody also blocked LPS-induced ACTH secretion in pituitary cell aggregates (700).
LPS Positive_regulation (induced) of Localization (secretion) of ACTH in pituitary
3) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.24 Pain Relevance 0.27

General Comments

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