INT222466

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.16
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gnrh1, Prl) extracellular space (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
median eminence 1
Gnrh1 (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 195 69.36 Quite High
agonist 110 7.68 Low Low
Nerve growth factor 140 5.00 Very Low Very Low Very Low
Inflammation 135 5.00 Very Low Very Low Very Low
cytokine 110 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 85 5.00 Very Low Very Low Very Low
substance P 80 5.00 Very Low Very Low Very Low
gABA 75 5.00 Very Low Very Low Very Low
Dopamine 65 5.00 Very Low Very Low Very Low
Glutamate 60 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 5 93.96 High High
Polycystic Ovary Syndrome 5 88.56 High High
Reprotox - General 1 5 87.12 High High
Eating Disorder 20 82.60 Quite High
Klinefelter Syndrome 5 81.08 Quite High
Galactorrhea 10 65.48 Quite High
Stress 240 5.00 Very Low Very Low Very Low
INFLAMMATION 140 5.00 Very Low Very Low Very Low
Cancer 110 5.00 Very Low Very Low Very Low
Targeted Disruption 110 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whatever the mechanism, it seems that the effect of GnRH on PRL release in vivo is complex due to the fact that it may be part of a communication network of which some components can compensate for each other and the behaviour of that system seems context-dependent.
GnRH Spec (seems) Regulation (effect) of PRL
1) Confidence 0.14 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.11 Pain Relevance 0
Moreover, PRL responses to GnRH during fetal and immature life could be based on different mechanisms than that observed in adult life or in certain pathological states.
GnRH Regulation (responses) of PRL
2) Confidence 0.09 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0
It should be noticed that all these data only show that there is a PRL response to GnRH in vivo but it cannot be distinguished where these effects are established by a paracrine mode of action or by an indirect action at the median eminence or by a direct action at the level of the lactotrophs.
GnRH Regulation (response) of PRL in median eminence
3) Confidence 0.09 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.39 Pain Relevance 0
Other studies only found a PRL response to GnRH in women during the periovulatory period and not during the late follicular or the midluteal phase (128–130).
GnRH Regulation (response) of PRL
4) Confidence 0.09 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.23 Pain Relevance 0.07
In men, a PRL response to GnRH was only seen after oestrogen treatment (139, 140).
GnRH Regulation (response) of PRL
5) Confidence 0.09 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.43 Pain Relevance 0

General Comments

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