INT222471

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a) extracellular space (Gnrh1)
extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
pituitary 1
Gnrh1 (Rattus norvegicus)
Pde5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 2 23.96 Low Low
antagonist 39 16.04 Low Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
cytokine 22 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Dopamine 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 7 67.04 Quite High
Targeted Disruption 22 30.40 Quite Low
Depression 2 23.96 Low Low
Stress 48 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is known that GnRH stimulates cGMP levels in pituitary in vitro (blockable by a NOS inhibitor) (520) and that treatment of pituitary slices with NO donors results in the appearance of cells expressing cGMP, mostly gonadotrophs but not FS cells (525).
GnRH Positive_regulation (stimulates) of cGMP in pituitary
1) Confidence 0.00 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.07 Pain Relevance 0

General Comments

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