INT222482

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.02
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep, Gh1) extracellular region (Lep, Gh1) mitochondrion (Gh1)
intracellular (Lep) lipid metabolic process (Lep) cytosol (Gh1)
Anatomy Link Frequency
pituitary 6
GH3 2
Lep (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 68 97.72 Very High Very High Very High
Enkephalin 8 77.36 Quite High
antagonist 156 77.28 Quite High
substance P 64 75.28 Quite High
agonist 88 23.44 Low Low
Nerve growth factor 112 5.00 Very Low Very Low Very Low
Inflammation 108 5.00 Very Low Very Low Very Low
cytokine 88 5.00 Very Low Very Low Very Low
gABA 60 5.00 Very Low Very Low Very Low
Dopamine 52 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Starvation 40 94.72 High High
Stress 192 5.00 Very Low Very Low Very Low
INFLAMMATION 112 5.00 Very Low Very Low Very Low
Cancer 88 5.00 Very Low Very Low Very Low
Targeted Disruption 88 5.00 Very Low Very Low Very Low
Pituitary Cancer 44 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 32 5.00 Very Low Very Low Very Low
Natriuresis 28 5.00 Very Low Very Low Very Low
Adhesions 24 5.00 Very Low Very Low Very Low
Hyperplasia 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In pig pituitary in vitro, leptin acutely increases GH secretion and, as in sheep, inhibits GHRH-stimulated GH release (450, 451).
leptin Positive_regulation (increases) of Localization (secretion) of GH in pituitary
1) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.44 Pain Relevance 0
In pig pituitary in vitro, leptin acutely increases GH secretion and, as in sheep, inhibits GHRH-stimulated GH release (450, 451).
leptin Positive_regulation (stimulated) of Localization (release) of GH in pituitary
2) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.45 Pain Relevance 0
Another potential role of pituitary leptin may be related to the GH axis during development because leptin can stimulate GH secretion at the level of the pituitary in human fetal pituitary in vitro (442).
leptin Positive_regulation (stimulate) of Localization (secretion) of GH in pituitary
3) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.13 Pain Relevance 0.12
Another valid candidate is leptin as it has been shown to stimulate GH secretion and to inhibit GH cell proliferation (GH3 cells) (236).
leptin Positive_regulation (stimulate) of Localization (secretion) of GH in GH3
4) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.09

General Comments

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