INT222490

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy, Gh1) extracellular region (Npy, Gh1) cytosol (Gh1)
signal transduction (Gh1) mitochondrion (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
pituitary 4
Npy (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 32 98.36 Very High Very High Very High
Enkephalin 4 97.28 Very High Very High Very High
Calcitonin gene-related peptide 34 93.32 High High
antagonist 78 72.88 Quite High
agonist 44 56.40 Quite High
Nerve growth factor 56 5.00 Very Low Very Low Very Low
Inflammation 54 5.00 Very Low Very Low Very Low
cytokine 44 5.00 Very Low Very Low Very Low
gABA 30 5.00 Very Low Very Low Very Low
Dopamine 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Starvation 20 58.52 Quite High
Eating Disorder 8 28.56 Quite Low
Stress 96 5.00 Very Low Very Low Very Low
INFLAMMATION 56 5.00 Very Low Very Low Very Low
Cancer 44 5.00 Very Low Very Low Very Low
Targeted Disruption 44 5.00 Very Low Very Low Very Low
Pituitary Cancer 22 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 16 5.00 Very Low Very Low Very Low
Natriuresis 14 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NPY has been reported to stimulate basal GH release (197) but to block the GH response to GHRH in porcine pituitary cells (231).
NPY Positive_regulation (stimulate) of Localization (release) of GH in pituitary
1) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.06 Pain Relevance 0.33
NPY stimulates basal GH secretion in rat pituitary cells loaded on a Bio-Gel P-2 column (237), in porcine monolayer cultures (238) and in gold fish pituitary fragments (239), but inhibits GHRH-stimulated GH release in porcine pituitary cultures (238).


NPY Positive_regulation (stimulates) of Localization (secretion) of GH in pituitary
2) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.08

General Comments

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