INT2225

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Context Info
Confidence 0.47
First Reported 1979
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 31
Total Number 32
Disease Relevance 11.78
Pain Relevance 8.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
spinal cord 3
margins 2
filament 2
astrocytes 2
brain 1
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 43 99.62 Very High Very High Very High
Inflammation 40 99.52 Very High Very High Very High
Spinal cord 221 99.42 Very High Very High Very High
midbrain 6 99.16 Very High Very High Very High
Hippocampus 21 98.76 Very High Very High Very High
dorsal root ganglion 15 98.66 Very High Very High Very High
IPN 2 98.56 Very High Very High Very High
ischemia 96 97.96 Very High Very High Very High
glial activation 13 97.80 Very High Very High Very High
Dorsal horn 43 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 48 99.52 Very High Very High Very High
Cancer 16 98.92 Very High Very High Very High
Spinal Cord Injury 134 98.72 Very High Very High Very High
Injury 329 98.66 Very High Very High Very High
Ganglion Cysts 15 98.66 Very High Very High Very High
Cv Unclassified Under Development 76 97.96 Very High Very High Very High
Infarction 9 97.88 Very High Very High Very High
Glioblastoma 10 97.36 Very High Very High Very High
Targeted Disruption 72 96.48 Very High Very High Very High
Rhinitis 1 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All of these ligands react with cell surface molecules except for anti-GFAP antibody which binds to intracellular glial filaments.
GFAP Binding (binds) of in filaments
1) Confidence 0.47 Published 1979 Journal Brain Res. Section Abstract Doc Link 385109 Disease Relevance 0.17 Pain Relevance 0.08
Furthermore, the tissue responses of PDMS implants coated with PVA/PAA IPN films were studied by 6-week implantation in the cortex of rats, which found that the glial fibrillary acidic protein (GFAP) immunoreactivity in animals (n=8) receiving coated implants was significantly lower (p<0.05) compared to that of uncoated implants (n=7) along the entire distance of 150 microm from the outer skirt to the implant interface.
glial fibrillary acidic protein Binding (found) of in cortex associated with ipn
2) Confidence 0.37 Published 2009 Journal Biomaterials Section Abstract Doc Link 19467702 Disease Relevance 0.09 Pain Relevance 0.31
DRG: dorsal root ganglion; CFA: complete Freund's adjuvant; NMDA: N-methyl-D-aspartic acid; GFAP, glial fibrillary acidic protein; Iba1: ionized calcium binding adaptor molecule 1; ATF3: activating transcription factor 3; Efnb2: ephrin-B2; CKO: conditional knockout.


GFAP Binding (calcium) of in dorsal root ganglion associated with targeted disruption, ganglion cysts and dorsal root ganglion
3) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.42 Pain Relevance 0.11
RESULTS: Compared with group A, the pain score, systolic pressure, the activity of AChE, the content of SP, and the positive index of c-Fos protein and GFAP of group B increased significantly (all P < 0.05); compared with group B, the pain score, AChE activity, the content of SP and the positive index of c-Fos protein and GFAP of both group C and group D decreased significantly (all P < 0.05); compared with group B, the content of LEK increased and systolic pressure decreased significantly in group C (both P < 0.05).
GFAP Binding (index) of in LEK
4) Confidence 0.36 Published 2010 Journal Zhongguo Zhen Jiu Section Body Doc Link 20886795 Disease Relevance 0.06 Pain Relevance 0
On day 28 or 42 (after a 14-day drug washout period), lumbar spinal cord sections were processed for assessment of astrocytic glial fibrillary acidic protein (GFAP) and microglial OX-42 (antibody against CR3/CD11b).
GFAP Binding (assessment) of in spinal cord associated with spinal cord
5) Confidence 0.36 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17544848 Disease Relevance 0.79 Pain Relevance 0.60
On day 28 or 42 (after a 14-day drug washout period), lumbar spinal cord sections were processed for assessment of astrocytic glial fibrillary acidic protein (GFAP) and microglial OX-42 (antibody against CR3/CD11b).
GFAP Binding (assessment) of in spinal cord associated with spinal cord
6) Confidence 0.36 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 16949251 Disease Relevance 0.79 Pain Relevance 0.60
In contrast, i.t. morphine caused a biphasic alteration in glial fibrillary acidic protein (GFAP) and integrin alpha M mRNA.
glial fibrillary acidic protein Binding (alteration) of associated with morphine
7) Confidence 0.36 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15743926 Disease Relevance 0.31 Pain Relevance 1.54
In contrast, i.t. morphine caused a biphasic alteration in glial fibrillary acidic protein (GFAP) and integrin alpha M mRNA.
GFAP Binding (alteration) of associated with morphine
8) Confidence 0.36 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15743926 Disease Relevance 0.31 Pain Relevance 1.54
Increased immunoreactivity for OX-42 (CR3/CD11b) and GFAP at various brain regions was also observed after the acute and subacute phases of the inflammation, respectively.
GFAP Binding (immunoreactivity) of in brain associated with inflammation
9) Confidence 0.36 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15233755 Disease Relevance 1.01 Pain Relevance 0.81
The present study extends this observation by showing that astrocytes in the rat lateral geniculate nucleus (LGN) also increase their immunoreactivity for glial fibrillary acidic protein (GFAP) soon after deprivation of afferent visual neuronal activity.
GFAP Binding (immunoreactivity) of in astrocytes
10) Confidence 0.36 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874503 Disease Relevance 0 Pain Relevance 0.10
The present study extends this observation by showing that astrocytes in the rat lateral geniculate nucleus (LGN) also increase their immunoreactivity for glial fibrillary acidic protein (GFAP) soon after deprivation of afferent visual neuronal activity.
glial fibrillary acidic protein Binding (immunoreactivity) of in astrocytes
11) Confidence 0.36 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874503 Disease Relevance 0 Pain Relevance 0.10
An examination of the specific regions of the brain revealed an increase in GFAP mRNA associated with the forebrain, midbrain, hippocampus and striatum.
GFAP Binding (associated) of in hippocampus associated with hippocampus and midbrain
12) Confidence 0.36 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1317493 Disease Relevance 0.28 Pain Relevance 0.29
The most marked changes in albumin and GFAP immunoreaction were seen after 2 weeks and persisted with mild intensities even after 10 weeks.
GFAP Binding (immunoreaction) of
13) Confidence 0.34 Published 2006 Journal Pain Section Abstract Doc Link 16806707 Disease Relevance 0.07 Pain Relevance 0.32
Furthermore, the immunocontent of GFAP and NF subunits was down-regulated, while vimentin was unaltered both in tissue homogenate and in cytoskeletal fraction of hypothyroid animals.
GFAP Binding (immunocontent) of
14) Confidence 0.33 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.30 Pain Relevance 0.17
In double labeled sections, BrdU-labeled were rarely associated with the GFAP-labeled astrocytic cell bodies located in the ventral portions of the nucleus (Fig. 2B) and with the IsoB4-labeled isolated microglial cells dispersed throughout the nucleus (Fig. 2D).
GFAP Binding (associated) of in ventral
15) Confidence 0.29 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079868 Disease Relevance 0 Pain Relevance 0
As shown in Fig. 5c, the increase in GFAP levels was seen at 3 d, 2 w and 8 w after ligation (p < 0.01).
GFAP Binding (ligation) of
16) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.63 Pain Relevance 0.33
However, a very small numbers of the cells expressed GFAP, a marker for astrocytes, O4, a marker for immature oligodendrocytes, and ?
GFAP Binding (marker) of in oligodendrocytes
17) Confidence 0.28 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2225502 Disease Relevance 0 Pain Relevance 0
After intrathecal injection of ketamine at P3, 7, or 21, spinal cords were examined for apoptosis (Fluoro-Jade C and activated caspase-3), histopathologic change, and glial responses (ionized calcium-binding adapter molecule 1 and glial fibrillary acid protein).
fibrillary acid protein Binding (binding) of in spinal cords
18) Confidence 0.24 Published 2010 Journal Anesthesiology Section Body Doc Link 20526188 Disease Relevance 0.08 Pain Relevance 0
In the penumbra, the immunoreactivity of NeuN and GFAP was unchanged after r-Hu-EPO treatment (Figs. 2B and C, I-R+EPO).
GFAP Binding (immunoreactivity) of
19) Confidence 0.22 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998786 Disease Relevance 0.48 Pain Relevance 0
The majority of GDAsCNTF retained their GFAP immunoreactivity after transplantation to acute spinal cord injury, particularly for those cells adjacent to injury margins (Figure 4a).
GFAP Binding (immunoreactivity) of in margins associated with injury and spinal cord
20) Confidence 0.19 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.65 Pain Relevance 0.08

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