INT222505

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.55
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Crh, Hpse) carbohydrate metabolic process (Hpse) response to stress (Crh)
cytoplasm (Crh) extracellular space (Crh) hydrolase activity, acting on glycosyl bonds (Hpse)
Crh (Rattus norvegicus)
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 27 91.96 High High
cytokine 22 75.72 Quite High
antagonist 39 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Dopamine 13 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 1 97.38 Very High Very High Very High
INFLAMMATION 28 91.96 High High
Targeted Disruption 22 88.00 High High
Stress 48 78.40 Quite High
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, also in mice infected with murine cytomegalovirus, IL-6 is mediating the activation of the HPA axis as shown by IL-6 immunoneutralisation in mice in which the central drive of the HPA axis is abolished by CRH gene deletion (686).
Gene_expression (deletion) of CRH gene Negative_regulation (abolished) of Gene_expression (axis) of HPA associated with cytomegalovirus infection
1) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.55 Pain Relevance 0.17

General Comments

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