INT222506

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Context Info
Confidence 0.20
First Reported 2008
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.16
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gnrh1, Prl) extracellular space (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
lactotrophs 2
Gnrh1 (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 39 82.00 Quite High
antagonist 117 5.00 Very Low Very Low Very Low
Nerve growth factor 84 5.00 Very Low Very Low Very Low
Inflammation 81 5.00 Very Low Very Low Very Low
cytokine 66 5.00 Very Low Very Low Very Low
agonist 66 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 51 5.00 Very Low Very Low Very Low
substance P 48 5.00 Very Low Very Low Very Low
gABA 45 5.00 Very Low Very Low Very Low
Glutamate 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Ovary Syndrome 3 54.00 Quite High
Reprotox - General 1 3 52.56 Quite High
Adhesions 18 52.48 Quite High
Eating Disorder 12 48.04 Quite Low
Klinefelter Syndrome 3 16.60 Low Low
Stress 144 5.00 Very Low Very Low Very Low
INFLAMMATION 84 5.00 Very Low Very Low Very Low
Cancer 66 5.00 Very Low Very Low Very Low
Targeted Disruption 66 5.00 Very Low Very Low Very Low
Pituitary Cancer 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whatever the mechanism, it seems that the effect of GnRH on PRL release in vivo is complex due to the fact that it may be part of a communication network of which some components can compensate for each other and the behaviour of that system seems context-dependent.
GnRH Spec (seems) Regulation (effect) of Localization (release) of PRL
1) Confidence 0.20 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.11 Pain Relevance 0
GnRH had no effect on PRL release, as expected.
GnRH Neg (no) Regulation (effect) of Localization (release) of PRL
2) Confidence 0.20 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.05 Pain Relevance 0
Thus, the GnRH effect on PRL release appeared to be mediated by gonadotrophs or required the presence of these cells in the vicinity of the lactotrophs.
GnRH Regulation (effect) of Localization (release) of PRL in lactotrophs
3) Confidence 0.20 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.08

General Comments

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