INT222516

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.11
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Calcrl, Ramp1) plasma membrane (Calcrl, Ramp1) endosome (Calcrl)
transport (Ramp1) endoplasmic reticulum (Calcrl) signal transducer activity (Calcrl)
Calcrl (Rattus norvegicus)
Ramp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 161 99.02 Very High Very High Very High
Calcitonin gene-related peptide 171 98.80 Very High Very High Very High
Spinal cord 5 93.12 High High
nMDA receptor 19 84.08 Quite High
Pain 49 60.80 Quite High
amygdala 87 55.44 Quite High
Dopamine 52 45.08 Quite Low
nMDA receptor antagonist 6 40.96 Quite Low
Neuronal excitability 9 5.08 Very Low Very Low Very Low
Nerve growth factor 112 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 48 60.80 Quite High
Stress 192 33.52 Quite Low
Nociception 4 13.52 Low Low
Starvation 40 8.88 Low Low
INFLAMMATION 113 5.00 Very Low Very Low Very Low
Targeted Disruption 88 5.00 Very Low Very Low Very Low
Cancer 88 5.00 Very Low Very Low Very Low
Pituitary Cancer 44 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 32 5.00 Very Low Very Low Very Low
Natriuresis 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional CGRP1 receptors are formed by a heterodimeric complex of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) [69,70].
calcitonin receptor-like receptor Binding (complex) of RAMP1
1) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.11 Pain Relevance 0.70
Calcitonin classically acts through the calcitonin receptor (CR), a GPCR, but the other calcitonin-like peptides act through a heterodimer consisting of the CR or the calcitonin receptor-like receptor (CLR), also a GPCR, and either one of the recently discovered ‘receptor activity-modifying proteins’ (RAMP-1, -2 and ?
CLR Binding (heterodimer) of RAMP-1
2) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.06
Calcitonin classically acts through the calcitonin receptor (CR), a GPCR, but the other calcitonin-like peptides act through a heterodimer consisting of the CR or the calcitonin receptor-like receptor (CLR), also a GPCR, and either one of the recently discovered ‘receptor activity-modifying proteins’ (RAMP-1, -2 and ?
calcitonin-like Binding (heterodimer) of RAMP-1
3) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.07
Most interesting in this respect is the compound BIBN4096BS, a nonpeptide CGRP antagonist that acts at the extracellular interface of the RAMP-1–CLR protein interaction (635), already indicating a proof of principle.
CLR Binding (interaction) of RAMP-1 associated with antagonist and calcitonin gene-related peptide
4) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.14
Most interesting in this respect is the compound BIBN4096BS, a nonpeptide CGRP antagonist that acts at the extracellular interface of the RAMP-1–CLR protein interaction (635), already indicating a proof of principle.
CLR Binding (interaction) of RAMP-1 associated with antagonist and calcitonin gene-related peptide
5) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.14

General Comments

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