INT222522

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 1.79
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1a, Il6) extracellular region (Il1a, Il6) cytosol (Il1a)
aging (Il6)
Anatomy Link Frequency
fibroblasts 6
anterior pituitary 2
Il1a (Rattus norvegicus)
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 418 99.92 Very High Very High Very High
Potency 37 99.92 Very High Very High Very High
cytokine 88 96.56 Very High Very High Very High
Inflammation 105 88.64 High High
Inflammatory stimuli 12 87.60 High High
Arthritis 66 87.08 High High
rheumatoid arthritis 108 83.20 Quite High
antagonist 39 36.24 Quite Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 124 88.64 High High
Experimental Arthritis 36 87.08 High High
Rheumatoid Arthritis 122 83.20 Quite High
Arthritis 48 76.56 Quite High
Kaposis Sarcoma 6 72.84 Quite High
Targeted Disruption 22 72.64 Quite High
Pressure And Volume Under Development 7 62.72 Quite High
Disease 26 56.56 Quite High
Obesity 10 50.52 Quite High
Cytomegalovirus Infection 1 44.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we compared the suppressive properties of the RAR agonist ATRA and of the RXR agonist, BMS-649, on IL-1-induced expression of IL-6 in rat synovial fibroblasts and tried to elucidate the corresponding molecular events with respect to the contribution of RAR/RXR subtypes and signalling pathways.
IL-1 Positive_regulation (induced) of Gene_expression (expression) of IL-6 in fibroblasts associated with agonist
1) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.88 Pain Relevance 0.65
Taken together, these data strongly suggested that the inhibition of the ERK1/2 pathway by ATRA supported its suppressive effect on IL-1-induced production of IL-6.
IL-1 Positive_regulation (induced) of Gene_expression (production) of IL-6 associated with agonist
2) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.25 Pain Relevance 0.40
As the RXR agonist (BMS-649) was inactive on IL-1-induced expression of IL-6 whereas the RAR agonist (ATRA) was inhibitory, we next investigated the contribution of the different RAR subtypes.
IL-1 Positive_regulation (induced) of Gene_expression (expression) of IL-6 associated with agonist
3) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0.46
Among RAR and RXR agonists, only ATRA inhibited IL-1-induced IL-6 expression in rat synovial fibroblasts by inhibiting ERK1/2 pathway and subsequent activation of AP-1 and NF-IL-6 independently of RAR.



IL-1 Positive_regulation (induced) of Gene_expression (expression) of IL-6 in fibroblasts associated with agonist
4) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656246 Disease Relevance 0.07 Pain Relevance 0.21
The present work demonstrated that ATRA, but several selective RAR agonists, displayed a powerful inhibitory potency on IL-1-induced expression and release of IL-6 by synovial fibroblasts.
IL-1 Positive_regulation (induced) of Gene_expression (expression) of IL-6 in fibroblasts associated with agonist and potency
5) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.21 Pain Relevance 0.39
Effect of RAR-selective agonists on IL-1-induced expression of IL-6
IL-1 Positive_regulation (induced) of Gene_expression (expression) of IL-6 associated with agonist
6) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.05 Pain Relevance 0.42
The production and release of IL-6 is stimulated by IL-1 in rat anterior pituitary cells in vitro (702) and IL-1 and IL-6 act synergistically in stimulating ACTH secretion in vivo (703).
IL-1 Positive_regulation (stimulated) of Gene_expression (production) of IL-6 in anterior pituitary
7) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.33 Pain Relevance 0.26

General Comments

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