INT22253

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Context Info
Confidence 0.32
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.53
Pain Relevance 6.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (KNG1, Calca) extracellular region (KNG1, Calca) aging (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Mention Frequency
nerves 2
KNG1 (Bos taurus)
Calca (Rattus norvegicus)
Pain Term Frequency Confidence Heat
Calcitonin gene-related peptide 29 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
qutenza 24 100.00 Very High Very High Very High
bradykinin 41 100.00 Very High Very High Very High
tetrodotoxin 4 99.24 Very High Very High Very High
antagonist 2 99.04 Very High Very High Very High
Kinase C 8 98.96 Very High Very High Very High
Calcium channel 8 98.48 Very High Very High Very High
Kinase C inhibitor 2 98.00 Very High Very High Very High
conotoxin 9 97.68 Very High Very High Very High
Disease Term Frequency Confidence Heat
Ganglion Cysts 3 94.00 High High
INFLAMMATION 4 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that: bradykinin stimulates CGRP secretion either by a direct effect or after applying so-called "bradykinin-priming" protocol.
bradykinin Positive_regulation (stimulates) of Localization (secretion) of CGRP associated with bradykinin
1) Confidence 0.32 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19285495 Disease Relevance 0 Pain Relevance 1.30
Bradykinin (10(-5)M) caused a 50% increase of the basal calcitonin gene-related peptide release which was again dependent on the presence of extracellular calcium, whereas serotonin and prostaglandin E(2) were each ineffective at 10(-5)M concentration.
Bradykinin Positive_regulation (caused) of Localization (release) of calcitonin associated with serotonin, bradykinin and calcitonin gene-related peptide
2) Confidence 0.13 Published 2000 Journal Neuroscience Section Abstract Doc Link 10858619 Disease Relevance 0.43 Pain Relevance 1.11
Our results indicate that moderate noxious heat induces calcium-dependent CGRP release and this can be facilitated by bradykinin and by the activation of PKC.
bradykinin Positive_regulation (facilitated) of Localization (release) of CGRP associated with kinase c, bradykinin and calcitonin gene-related peptide
3) Confidence 0.09 Published 1999 Journal Pain Section Abstract Doc Link 10534601 Disease Relevance 0 Pain Relevance 0.61
Bradykinin 10 but not 1 microM as well as PMA 1 and 10 microM significantly facilitated the heat-induced CGRP release at 47 degrees C whereby BK caused a marginal and PMA a significant CGRP release by itself.
Bradykinin Positive_regulation (facilitated) of Localization (release) of CGRP associated with bradykinin and calcitonin gene-related peptide
4) Confidence 0.08 Published 1999 Journal Pain Section Abstract Doc Link 10534601 Disease Relevance 0 Pain Relevance 0.74
Bradykinin-induced release of calcitonin gene-related peptide from capsaicin-sensitive nerves in guinea-pig atria: mechanism of action and calcium requirements.
Bradykinin Positive_regulation (induced) of Localization (release) of calcitonin in nerves associated with qutenza, bradykinin and calcitonin gene-related peptide
5) Confidence 0.06 Published 1990 Journal Neuroscience Section Title Doc Link 2270140 Disease Relevance 0 Pain Relevance 1.11
Bradykinin-induced calcitonin gene-related peptide-like immunoreactive release was unaffected by tetrodotoxin (0.3 microM), the protein kinase C inhibitor, 1-(5-isoquinolinesulphonyl)-2-methylpiperazine (30 microM), nefedipine (1 microM) or Ruthenium Red (10 microM).
Bradykinin Positive_regulation (induced) of Localization (release) of calcitonin associated with tetrodotoxin, bradykinin, kinase c inhibitor and calcitonin gene-related peptide
6) Confidence 0.05 Published 1990 Journal Neuroscience Section Abstract Doc Link 2270140 Disease Relevance 0 Pain Relevance 1.13
Bradykinin-stimulated release of immunoreactive substance P (iSP) and calcitonin gene-related peptide (iCGRP) was attenuated by the N-type VSCC blocker, omega-conotoxin GVIA (100 nM), but was unaffected by blockade of L-type (1 microM nifedipine) or P-type (200 nM omega-agatoxin IVA) VSCC.
Bradykinin Positive_regulation (stimulated) of Localization (release) of calcitonin gene-related peptide associated with calcium channel, bradykinin, conotoxin, calcitonin gene-related peptide and substance p
7) Confidence 0.00 Published 1996 Journal Brain Res. Section Abstract Doc Link 8814901 Disease Relevance 0.09 Pain Relevance 0.77

General Comments

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