INT222531

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.61
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Il6, Hpse) aging (Il6) carbohydrate metabolic process (Hpse)
extracellular space (Il6) hydrolase activity, acting on glycosyl bonds (Hpse) cell adhesion (Hpse)
Il6 (Rattus norvegicus)
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 27 88.08 High High
cytokine 22 71.84 Quite High
antagonist 39 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Dopamine 13 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 48 92.48 High High
Cytomegalovirus Infection 1 90.88 High High
INFLAMMATION 28 88.08 High High
Targeted Disruption 22 84.12 Quite High
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Remarkably, in mice deficient in either CRH or IL-6, LPS activates the HPA axis less than in wild-type mice but significantly more than in mice deficient in both CRH and IL-6 (705), suggesting the appearance of compensatory mechanisms during severe depletion of stress mediators.
IL-6 Positive_regulation (activates) of HPA associated with stress
1) Confidence 0.00 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.61 Pain Relevance 0.18

General Comments

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