INT222539

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

growth (Inhba) extracellular region (Inhba) cytoplasm (Acvr2a)

Inhba (Rattus norvegicus) Acvr2a (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 39 39.68 agonist 22 21.96 Nerve growth factor 28 5.00 Inflammation 27 5.00 cytokine 22 5.00 Calcitonin gene-related peptide 17 5.00 substance P 16 5.00 gABA 15 5.00 Dopamine 13 5.00 Glutamate 12 5.00

Disease Link Frequency Relevance Heat Stress 48 5.00 INFLAMMATION 28 5.00 Cancer 22 5.00 Targeted Disruption 22 5.00 Pituitary Cancer 11 5.00 Starvation 10 5.00 Rheumatoid Arthritis 8 5.00 Natriuresis 7 5.00 Adhesions 6 5.00 Hyperplasia 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This glycoprotein binds activin and in this way masks the binding domain of the activin molecule, preventing it from binding to the Act-R-II; consequently, activation of Act-R-I does not occur (472), resulting in bio-neutralisation of activin.

Negative_regulation (preventing) of activin Binding (binding) of Act-R-II

1) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0

General Comments

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