INT222545

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.52
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
pituitary 2
Lep (Rattus norvegicus)
Nmb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 12 93.72 High High
antagonist 78 5.00 Very Low Very Low Very Low
Nerve growth factor 56 5.00 Very Low Very Low Very Low
Inflammation 54 5.00 Very Low Very Low Very Low
cytokine 44 5.00 Very Low Very Low Very Low
agonist 44 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 34 5.00 Very Low Very Low Very Low
substance P 32 5.00 Very Low Very Low Very Low
gABA 30 5.00 Very Low Very Low Very Low
Dopamine 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Disease 8 87.40 High High
Diabetes Mellitus 2 82.24 Quite High
Starvation 20 76.16 Quite High
Stress 96 10.76 Low Low
INFLAMMATION 56 5.00 Very Low Very Low Very Low
Cancer 44 5.00 Very Low Very Low Very Low
Targeted Disruption 44 5.00 Very Low Very Low Very Low
Pituitary Cancer 22 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 16 5.00 Very Low Very Low Very Low
Natriuresis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NMB autocrine loop is physiologically related to energy homeostasis, as TRH and leptin rapidly decrease pituitary NMB levels, which, in turn, might increase the efficacy of TRH on TSH release (644).
leptin Negative_regulation (decrease) of NMB in pituitary
1) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.26 Pain Relevance 0.05
Leptin decreases pituitary NMB levels (644).
Leptin Negative_regulation (decreases) of NMB in pituitary
2) Confidence 0.03 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.27 Pain Relevance 0.04

General Comments

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