INT222546

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl) endoplasmic reticulum (Mzb1) molecular_function (Mzb1)
cytoplasm (Mzb1)
Anatomy Link Frequency
pituitary 2
Mzb1 (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 2 62.88 Quite High
Calcitonin gene-related peptide 34 57.04 Quite High
cytokine 44 54.56 Quite High
agonist 44 20.44 Low Low
antagonist 78 5.00 Very Low Very Low Very Low
Nerve growth factor 56 5.00 Very Low Very Low Very Low
Inflammation 54 5.00 Very Low Very Low Very Low
substance P 32 5.00 Very Low Very Low Very Low
gABA 30 5.00 Very Low Very Low Very Low
Dopamine 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 14 59.72 Quite High
Stress 96 52.08 Quite High
INFLAMMATION 56 5.00 Very Low Very Low Very Low
Cancer 44 5.00 Very Low Very Low Very Low
Targeted Disruption 44 5.00 Very Low Very Low Very Low
Pituitary Cancer 22 5.00 Very Low Very Low Very Low
Starvation 20 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 16 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low
Hyperplasia 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In studies where a stimulation of PRL release by PACAP was found in monolayer culture, the effect is probably on PRL gene expression and translation as it was only found after several hours of treatment (213).
PACAP Positive_regulation (stimulation) of Localization (release) of PRL
1) Confidence 0.10 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.12 Pain Relevance 0.09
In monolayers or in a reverse haemolytic plaque assay system, PACAP inhibits PRL release and has no effect on GH release but PACAP stimulates both GH and PRL release in pituitary tissue blocks and in aggregates as well as in vivo in rats with hypothalamic lesions (in which hypothalamic-releasing hormone influence is abolished) (207).
PACAP Positive_regulation (stimulates) of Localization (release) of PRL in pituitary
2) Confidence 0.08 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

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