INT222548

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.70
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il11, Pomc) extracellular region (Il11, Pomc) cytoplasm (Il11, Pomc)
signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) molecular_function (Pomc)
Anatomy Link Frequency
corticotroph 2
Il11 (Rattus norvegicus)
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 22 88.00 High High
Inflammation 27 78.84 Quite High
antagonist 39 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 17 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
gABA 15 5.00 Very Low Very Low Very Low
Dopamine 13 5.00 Very Low Very Low Very Low
Glutamate 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 48 91.16 High High
Targeted Disruption 22 89.00 High High
INFLAMMATION 28 78.84 Quite High
Cytomegalovirus Infection 1 47.16 Quite Low
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In human and murine pituitary, IL-11 and IL-11-R mRNA expression has been demonstrated and, as far as tested in corticotroph AtT-20 cells, IL-11 stimulates ACTH secretion and POMC gene transcription (710).
IL-11 Positive_regulation (stimulates) of Transcription (transcription) of POMC gene in corticotroph
1) Confidence 0.03 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.70 Pain Relevance 0.16

General Comments

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